Literature DB >> 7099355

Behavioral effects of prenatal exposure to nicotine in guinea pigs.

J M Johns, T M Louis, R F Becker, L W Means.   

Abstract

Nicotine (3 mg/kg SC) administered twice daily throughout pregnancy to guinea pigs resulted in offspring that were behaviorally deficient both as neonates and adults. The nicotine-treated offspring showed reduced spontaneous alternation both as neonates and adults. Also, the nicotine-treated offspring were less likely to enter a novel alley as neonates and were deficient on brightness discrimination and reversal as adults.

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Year:  1982        PMID： 7099355

Source DB:  PubMed          Journal:  Neurobehav Toxicol Teratol        ISSN： 0275-1380


  14 in total

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