Literature DB >> 7099251

Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9.

J Tschopp, H J Müller-Eberhard, E R Podack.   

Abstract

The ninth component of complement C9 can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.

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Year:  1982        PMID： 7099251     DOI： 10.1038/298534a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  53 in total

Review 1.  Perforin and its role in T lymphocyte-mediated cytolysis.

Authors:  B Lowin; O Krähenbühl; C Müller; M Dupuis; J Tschopp
Journal:  Experientia       Date:  1992-10-15

2.  Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp.

Authors:  J A Trapani
Journal:  Cell Death Differ       Date:  2011-11-18       Impact factor: 15.828

3.  Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

Authors:  Alexander E Aleshin; Richard G DiScipio; Boguslaw Stec; Robert C Liddington
Journal:  J Biol Chem       Date:  2012-04-12       Impact factor: 5.157

4.  Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.

Authors:  D R Wren; M Noble
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

5.  Mutation of recombinant complement component C9 reveals the significance of the N-terminal region for polymerization.

Authors:  K M Taylor; A R Trimby; A K Campbell
Journal:  Immunology       Date:  1997-05       Impact factor: 7.397

6.  Pore-forming peptide of pathogenic Entamoeba histolytica.

Authors:  M Leippe; S Ebel; O L Schoenberger; R D Horstmann; H J Müller-Eberhard
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-01       Impact factor: 11.205

7.  Functional channel formation associated with cytotoxic T-cell granules.

Authors:  J D Young; C F Nathan; E R Podack; M A Palladino; Z A Cohn
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

8.  Single-channel analysis of the conductance fluctuations induced in lipid bilayer membranes by complement proteins C5b-9.

Authors:  R Benz; A Schmid; T Wiedmer; P J Sims
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

9.  Multimeric complement component C9 is necessary for killing of Escherichia coli J5 by terminal attack complex C5b-9.

Authors:  K A Joiner; M A Schmetz; M E Sanders; T G Murray; C H Hammer; R Dourmashkin; M M Frank
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205

10.  Hepatitis C virus suppresses C9 complement synthesis and impairs membrane attack complex function.

Authors:  Hangeun Kim; Keith Meyer; Adrian M Di Bisceglie; Ranjit Ray
Journal:  J Virol       Date:  2013-03-13       Impact factor: 5.103
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