| Literature DB >> 7097726 |
M E Safdy, E Kurchacova, R N Schut, H Vidrio, E Hong.
Abstract
A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.Entities:
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Year: 1982 PMID： 7097726 DOI： 10.1021/jm00348a022
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446