Literature DB >> 7097543

The measurement of theophylline metabolism in hepatic microsomes using high-performance liquid chromatography.

T C Hemsworth, K W Renton.   

Abstract

A method is described to measure the in vitro metabolism of theophylline by liver microsomes. The formation of 1-methyluric acid and 1,3-dimethyluric acid in incubation mixtures was determined by high-performance liquid chromatography. The formation of both metabolites was linear with time and the formation of 1-methyluric acid was blocked by allopurinol. This method will be useful in assessing potential drug interactions involving theophylline.

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Year:  1982        PMID： 7097543     DOI： 10.1002/jps.2600710628

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  2 in total

1.  Determination of some anticonvulsants, antiarrhythmics, benzodiazepines, xanthines, paracetamol and chloramphenicol by reversed phase HPLC.

Authors:  H J Willems; A Van der Horst; P N De Goede; G J Haakmeester
Journal:  Pharm Weekbl Sci       Date:  1985-08-23

2.  Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit.

Authors:  A Bouraoui; J L Brazier; H Zouaghi; M Rousseau
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1995 Jul-Sep       Impact factor: 2.441
  2 in total

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