Literature DB >> 7097517

Use of unbound drug concentration in blood to discriminate between two models of hepatic drug elimination.

D J Morgan, K Raymond.   

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Year:  1982        PMID： 7097517     DOI： 10.1002/jps.2600710536

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


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  5 in total

1.  Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophilic drugs.

Authors:  L P Rivory; M S Roberts; S M Pond
Journal:  J Pharmacokinet Biopharm       Date:  1992-02

2.  Reassessing models of hepatic extraction.

Authors:  D Ridgway; J A Tuszynski; Y K Tam
Journal:  J Biol Phys       Date:  2003-03       Impact factor: 1.365

3.  A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity.

Authors:  M S Roberts; M Rowland
Journal:  J Pharmacokinet Biopharm       Date:  1986-06

4.  Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: comparison of venous equilibrium, undistributed and distributed sinusoidal, and dispersion models.

Authors:  R H Smallwood; D J Morgan; G W Mihaly; D B Jones; R A Smallwood
Journal:  J Pharmacokinet Biopharm       Date:  1988-08

5.  Protein binding and hepatic clearance: discrimination between models of hepatic clearance with diazepam, a drug of high intrinsic clearance, in the isolated perfused rat liver preparation.

Authors:  M Rowland; D Leitch; G Fleming; B Smith
Journal:  J Pharmacokinet Biopharm       Date:  1984-04
  5 in total

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