Induced venous pooling and cardiorespiratory responses to exercise after bed rest.

The purpose of this study was to deliberately induce venous pooling the lower extremities of bed-rested subjects to determine whether such distention may reverse the reduction in maximal O2 uptake that has regularly been observed. Bed-rest deconditioning was assessed in eight healthy male subjects by measuring submaximal and maximal O2 uptake (VO2 max), ventilation, and heart rate (HRmax) before and after 15 days of bed rest. During bed rest four subjects in the experimental group received daily treatments of venous pooling for 210 min/day with a reverse gradient garment (RGG), whereas the four subjects in the control group received no treatment. Compared with prebed-rest values, VO2max was reduced by 14.0 (P less than 0.05), HRmax was increased by 4.2 (P less than 0.05), and endurance time for the exercise test was decreased by 9.2% (P less than 0.05) in the control group. In the RGG group, VO2max, HRmax, and endurance time were essentially unchanged after bed rest. The plasma volume (PV) of the control group decreased by 16.7 (P less than 0.05) after bed rest compared with a 10.3% (not significant) reduction in the RGG group. The percent delta PV was related to the percent delta VO2 max (r = 0.75, P less than 0.05) and percent delta HR max (r = 0.65, P less than 0.05). The data support the hypothesis that the lack of venous pooling and associated fluid shifts contribute the decrement in VO2 max associated with bed-rest deconditioning.

RCT Entities:   Population Interventions Outcomes