Literature DB >> 7095099

Nicotine and ascorbic acid effects on cold-restraint ulcers in rats.

G B Glavin, L Lagrotteria.   

Abstract

Rats were orally administered 1-ascorbic acid, nicotine 1-ascorbic acid and nicotine, or distilled water for 10 days. Following this treatment they were fasted for 24 h and then restrained in a cold environment for 2 h. Nicotine alone produced significantly more gastric ulcers than any other treatment. 1-Ascorbic acid increased ulceration relative to controls. The combined effects of 1-ascorbic acid and nicotine resulted in reduced ulcer incidence and severity. It appears that l-ascorbic acid and nicotine do not act synergistically to augment stress-induced gastric ulcer.

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Year:  1982        PMID： 7095099     DOI： 10.1007/BF02327073

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Effect of cigarette smoking on gastric secretions of patients with duodenal ulcer.

Authors:  P COOPER; J B KNIGHT
Journal:  N Engl J Med       Date:  1956-07-05       Impact factor: 91.245

2.  Effects of smoking tobacco on gastric acidity and motility of hospital controls and patients with peptic ulcer.

Authors:  F STEIGMANN; R H DOLEHIDE; L KAMINSKI
Journal:  Am J Gastroenterol       Date:  1954-11       Impact factor: 10.864

3.  Oral nicotine ingestion and incidence of activity-stress ulcer in the rat.

Authors:  W P Paré
Journal:  Biochem Med       Date:  1975-09

4.  Body orientation, food deprivation and potentiation of restraint induced gastric lesions.

Authors:  G Vincent; G Glavin; J Rutkowski; W Paré
Journal:  Gastroenterol Clin Biol       Date:  1977 Jun-Jul

5.  Possible relationship between smoking and peptic ulcer.

Authors:  A Robert; D F Stowe; J E Nezamis
Journal:  Nature       Date:  1971-10-15       Impact factor: 49.962

6.  Effects of nicotine and tobacco smoke on gastric secretion in rats with gastric fistulas.

Authors:  J H Thompson
Journal:  Am J Dig Dis       Date:  1970-03

7.  Synergistic effect of vitamin C and aspirin on gastric lesions in the rat.

Authors:  G Y Lo; F Konishi
Journal:  Am J Clin Nutr       Date:  1978-08       Impact factor: 7.045

8.  Potentiation, by nicotine, of duodenal ulcers in the rat.

Authors:  A Robert
Journal:  Proc Soc Exp Biol Med       Date:  1972-01

9.  Ascorbic acid and stress ulcer in the rat.

Authors:  G B Glavin; W P Paré; G P Vincent
Journal:  J Nutr       Date:  1978-12       Impact factor: 4.798
  9 in total
  2 in total

1.  Aggravation of gastric mucosal lesions in rat stomach by tobacco cigarette smoke.

Authors:  F Iwata; X Y Zhang; F W Leung
Journal:  Dig Dis Sci       Date:  1995-05       Impact factor: 3.199

2.  Melatonin is more effective than ascorbic acid and β-carotene in improvement of gastric mucosal damage induced by intensive stress.

Authors:  Aysin Akinci; Mukaddes Esrefoglu; Asli Cetin; Burhan Ates
Journal:  Arch Med Sci       Date:  2015-10-12       Impact factor: 3.318
  2 in total

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