Literature DB >> 70945

Cyclic AMP and allergic histamine release. Influence of methylxanthines on rat mast cells.

S Norn, A Geisler, P Stahl Skov, R Klysner.   

Abstract

Both isobutylmethylxanthine and theophylline increased the level of cyclic AMP in rat mast cells. Theophylline reduced the allergic histamine release, whereas isobutylmethylxanthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is inadequate.

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Year:  1977        PMID： 70945     DOI： 10.1111/j.1398-9995.1977.tb01348.x

Source DB:  PubMed          Journal:  Acta Allergol        ISSN： 0001-5148


  4 in total

1.  Effects of [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3',5'-nucleotide formation and phosphodiesterase activity.

Authors:  T A Pugsley; W Lippmann
Journal:  Experientia       Date:  1979-01-15

2.  Differentiation between cyclic AMP level and allergic histamine release in mast cells [proceedings].

Authors:  S Norn; A Geisler; P S Skov; R Klysner
Journal:  Agents Actions       Date:  1979-04

3.  Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs.

Authors:  S T Holgate; R A Lewis; K F Austen
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

Review 4.  The human lung mast cell.

Authors:  S I Wasserman
Journal:  Environ Health Perspect       Date:  1984-04       Impact factor: 9.031
  4 in total

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