Literature DB >> 7093972

Phase II study of sequential methotrexate-5-FU therapy in advanced measurable colorectal cancer.

J E Cantrell, R Brunet, C Lagarde, P S Schein, F P Smith.   

Abstract

Eighteen patients with previously untreated advanced colorectal cancer were treated with a sequential methotrexate-5-FU regimen. One of 16 evaluable patients achieved a partial response. The results of this and other clinical and laboratory investigations reported to date suggest that further study of different doses and schedules of sequential methotrexate-5-FU is warranted.

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Year:  1982        PMID： 7093972

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  4 in total

1.  A phase II study of sequential methotrexate and 5-fluorouracil in colorectal carcinoma.

Authors:  M J Harding; S B Kaye; M Soukop; J C Ferguson
Journal:  Med Oncol Tumor Pharmacother       Date:  1988

2.  Sequential methotrexate (MTX) and 5-fluorouracil (FU) in human tumor xenografts.

Authors:  K Wayss; R Herrmann; J Mattern; M Volm
Journal:  Med Oncol Tumor Pharmacother       Date:  1985

Review 3.  Biochemical mechanisms in colon xenografts: thymidylate synthase as a target for therapy.

Authors:  P J Houghton; J A Houghton; B J Hazelton; S Radparvar
Journal:  Invest New Drugs       Date:  1989-04       Impact factor: 3.850

4.  Update in cancer chemotherapy: gastrointestinal cancer--colorectal cancer, Part 2.

Authors:  J C Wright
Journal:  J Natl Med Assoc       Date:  1986-05       Impact factor: 1.798
  4 in total

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