Literature DB >> 7093943

The main photosensitizing components of hematoporphyrin derivative.

J Moan, T Christensen, S Sommer.   

Abstract

Commercial hematoporphyrin (Hp) and the tumor-localizing and photosensitizing agent hematoporphyrin derivative (Hpd) were analysed by means of high pressure lipid chromatography (HPLC). Furthermore, their efficiencies in sensitizing the photoinactivation of human cells in vitro were compared. The comparison showed that the least polar components of Hpd played the major role in this sensitization. In Hpd solutions used for injection in photochemotherapeutic treatment of cancer, these active components seem to be present as aggregates.

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Year:  1982        PMID： 7093943     DOI： 10.1016/0304-3835(82)90046-5

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

1.  Porphyrin-sensitized photoinactivation of human cells in vitro.

Authors:  J Moan; J V Johannessen; T Christensen; T Espevik; J B McGhie
Journal:  Am J Pathol       Date:  1982-11       Impact factor: 4.307

2.  Biological and biophysical properties of the tumor-localizing component of hematoporphyrin derivative.

Authors:  D Kessel; M L Cheng
Journal:  Cancer Res       Date:  1985-07       Impact factor: 12.701

3.  Penetration of hematoporphyrin derivative into rat brain and intracerebral 9L glioma tissue.

Authors:  D P Boisvert; J D McKean; J Tulip; J Cummins; M K Cheng
Journal:  J Neurooncol       Date:  1985       Impact factor: 4.130

4.  Cellular effects of hematoporphyrin derivative photodynamic therapy on normal and neoplastic rat bladder cells.

Authors:  J R Shulok; J E Klaunig; S H Selman; P J Schafer; P J Goldblatt
Journal:  Am J Pathol       Date:  1986-02       Impact factor: 4.307

5.  Thermodynamics of porphyrin dimerization in aqueous solutions.

Authors:  R Margalit; M Rotenberg
Journal:  Biochem J       Date:  1984-04-15       Impact factor: 3.857

6.  Morphologic studies of bladder tumors treated with hematoporphyrin derivative photochemotherapy.

Authors:  J E Klaunig; S H Selman; J R Shulok; P J Schafer; S L Britton; P J Goldblatt
Journal:  Am J Pathol       Date:  1985-05       Impact factor: 4.307

7.  In vitro photosensitization of tumour cell enzymes by photofrin II administered in vivo.

Authors:  S L Gibson; R S Murant; M D Chazen; M E Kelly; R Hilf
Journal:  Br J Cancer       Date:  1989-01       Impact factor: 7.640

8.  Retention and photodynamic effects of haematoporphyrin derivative in cells after prolonged cultivation in the presence of porphyrin.

Authors:  T Christensen; T Sandquist; K Feren; H Waksvik; J Moan
Journal:  Br J Cancer       Date:  1983-07       Impact factor: 7.640

9.  Effects of photodynamic therapy on xenografts of human mesothelioma and rat mammary carcinoma in nude mice.

Authors:  S L Gibson; T H Foster; R H Feins; R F Raubertas; M A Fallon; R Hilf
Journal:  Br J Cancer       Date:  1994-03       Impact factor: 7.640
  9 in total

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