Literature DB >> 7093709

Decreased serotonin turnover in the dorsal hippocampus of rat brain shortly after adrenalectomy: selective normalization after corticosterone substitution.

E R De Kloet, G L Kovács, G Szabó, G Telegdy, B Bohus, D H Versteeg.   

Abstract

Pargyline-induced accumulation of serotonin (5-HT) was used as an index of 5-HT turnover rate in the dorsal hippocampus. One hour after bilateral removal of the adrenals, 5-HT turnover was significantly reduced when compared to that of the sham-operated controls. A low dose of corticosterone given immediately after adrenalectomy restored the 5-HT response, while the same dose of dexamethasone was ineffective. Pretreatment with dexamethasone blocked the 5-HT response to corticosterone in the acutely adrenalectomized rat. The specificity of the 5-HT response in the hippocampus corresponds to the properties of the glucocorticoid receptor system in rat hippocampal neurons.

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Year:  1982        PMID： 7093709     DOI： 10.1016/0006-8993(82)90546-7

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  17 in total

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Review 5.  Functional implications of brain corticosteroid receptor diversity.

Authors:  E R de Kloet; M S Oitzl; M Joëls
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6.  Acute changes in dopamine metabolism in the medio-basal hypothalamus following adrenalectomy.

Authors:  D H Versteeg; I Van Zoest; E R De Kloet
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7.  Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus.

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8.  Regulation of corticosteroid receptor gene expression in depression and antidepressant action.

Authors:  N Barden
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10.  Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure.

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