Literature DB >> 7092845

Ca2+- and calmodulin-dependent protein phosphorylation in rat lacrimal gland.

D A Dartt, V J Guerina, M Donowitz, L Taylor, G W Sharp.   

Abstract

Ca2+, in homogenized lacrimal glands, enhanced phosphorylation of several peptides. Phosphorylation of two of these peptides was further stimulated by addition of the Ca2+-binding protein calmodulin and decreased by trifluoperazine, an inhibitor of Ca2+--calmodulin-dependent activity. Thus, Ca2+--calmodulin-dependent protein kinases and their substrates are present in lacrimal gland and could have an important role in lacrimal-gland function.

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Year:  1982        PMID: 7092845      PMCID: PMC1158179          DOI: 10.1042/bj2020799

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  15 in total

1.  The role of calcium in the receptor mediated control of potassium permeability in the rat lacrimal gland.

Authors:  R J Parod; J W Putney
Journal:  J Physiol       Date:  1978-08       Impact factor: 5.182

2.  Role of Ca(2+)-dependent regulator protein in intestinal secretion.

Authors:  A Ilundain; R J Naftalin
Journal:  Nature       Date:  1979-05-31       Impact factor: 49.962

3.  Control by calcium of protein discharge and membrane permeability to potassium in the rat lacrimal gland.

Authors:  J W Putney; R J Parod; S H Marier
Journal:  Life Sci       Date:  1977-06-01       Impact factor: 5.037

4.  Chlorpromazine inhibits phagocytosis and exocytosis in rabbit polymorphonuclear leukocytes.

Authors:  J G Elferink
Journal:  Biochem Pharmacol       Date:  1979-04-01       Impact factor: 5.858

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Stimulation of 45Ca efflux from rat lacrimal gland slices by carbachol and epinephrine.

Authors:  R J Parod; J W Putney
Journal:  Life Sci       Date:  1979-12-24       Impact factor: 5.037

7.  Effect of calcium antagonism or chelation on rabbit lacrimal gland secretion and membrane potentials.

Authors:  S Y Botelho; D A Dartt
Journal:  J Physiol       Date:  1980-07       Impact factor: 5.182

8.  Effect of carbachol on 45Ca uptake and protein secretion in rat lacrimal gland.

Authors:  G Keryer; B Rossignol
Journal:  Am J Physiol       Date:  1976-01

9.  Possible role for calmodulin in insulin release. Studies with trifluoperazine in rat pancreatic islets.

Authors:  Y Krausz; C B Wollheim; E Siegel; G W Sharp
Journal:  J Clin Invest       Date:  1980-09       Impact factor: 14.808

10.  Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

Authors:  T Mori; Y Takai; R Minakuchi; B Yu; Y Nishizuka
Journal:  J Biol Chem       Date:  1980-09-25       Impact factor: 5.157

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  2 in total

1.  Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues.

Authors:  A C Nairn; B Bhagat; H C Palfrey
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

Review 2.  Protein phosphorylation in the pancreatic B-cell.

Authors:  D E Harrison; S J Ashcroft; M R Christie; J M Lord
Journal:  Experientia       Date:  1984-10-15
  2 in total

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