Literature DB >> 7090418

The metabolism of pyrene by rat liver microsomes and the influence of various mono-oxygenase inducers.

J Jacob, G Grimmer, G Raab, A Schmoldt.   

Abstract

1. Pyrene metabolite g.l.c. profiles were recorded and metabolites identified by mass spectrometry. 2. Pyrene is metabolized by liver microsomes of untreated rats to 1-hydroxypyrene, 4,5-dihydroxy-4,5-dihydropyrene, two different diphenols and a triol, tentatively identified as 1,4,5-trihydroxy-4,5-dihydropyrene. 3. Pretreatment with phenobarbital or polychlorinated biphenyls favours oxidation at the K-region, whereas cytochrome P-448 inducers stimulate oxidation at the non-K-region of pyrene. 4. 1-Hydroxypyrene does not inhibit pyrene oxidation. 5. Pyrene diphenols are formed by secondary oxidation of 1-hydroxypyrene. 6. Triols are formed from dihydrodiols by secondary oxidation.

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Year:  1982        PMID： 7090418     DOI： 10.3109/00498258209052453

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  13 in total

1.  Pyrene Metabolism in Crinipellis stipitaria: Identification of trans-4,5-Dihydro-4,5-Dihydroxypyrene and 1-Pyrenylsulfate in Strain JK364.

Authors:  B Lange; S Kremer; O Sterner; H Anke
Journal:  Appl Environ Microbiol       Date:  1994-10       Impact factor: 4.792

2.  Metabolism of Pyrene by the Basidiomycete Crinipellis stipitaria and Identification of Pyrenequinones and Their Hydroxylated Precursors in Strain JK375.

Authors:  M Lambert; S Kremer; O Sterner; H Anke
Journal:  Appl Environ Microbiol       Date:  1994-10       Impact factor: 4.792

3.  Simulation of urinary excretion of 1-hydroxypyrene in various scenarios of exposure to polycyclic aromatic hydrocarbons with a generic, cross-chemical predictive PBTK-model.

Authors:  Frans Jongeneelen; Wil ten Berge
Journal:  Int Arch Occup Environ Health       Date:  2011-10-29       Impact factor: 3.015

4.  Urinary 1-hydroxypyrene in coke oven workers relative to exposure, alcohol consumption, and metabolic enzymes.

Authors:  J Zhang; M Ichiba; K Hara; S Zhang; T Hanaoka; G Pan; Y Yamano; K Takahashi; K Tomokuni
Journal:  Occup Environ Med       Date:  2001-11       Impact factor: 4.402

5.  An examination of the time course from human dietary exposure to polycyclic aromatic hydrocarbons to urinary elimination of 1-hydroxypyrene.

Authors:  T J Buckley; P J Lioy
Journal:  Br J Ind Med       Date:  1992-02

6.  Metabolism of the polycyclic aromatic hydrocarbon pyrene by Aspergillus niger SK 9317.

Authors:  T Wunder; S Kremer; O Sterner; H Anke
Journal:  Appl Microbiol Biotechnol       Date:  1994-12       Impact factor: 4.813

7.  Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols).

Authors:  G Grimmer; G Dettbarn; J Jacob
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

8.  Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13.

Authors:  Tsutomu Shimada; Shigeo Takenaka; Norie Murayama; Valerie M Kramlinger; Joo-Hwan Kim; Donghak Kim; Jiawang Liu; Maryam K Foroozesh; Hiroshi Yamazaki; F Peter Guengerich; Masayuki Komori
Journal:  Xenobiotica       Date:  2015-08-06       Impact factor: 1.908

9.  Pyrene degradation by a Mycobacterium sp.: identification of ring oxidation and ring fission products.

Authors:  M A Heitkamp; J P Freeman; D W Miller; C E Cerniglia
Journal:  Appl Environ Microbiol       Date:  1988-10       Impact factor: 4.792

10.  Microbial metabolism of polycyclic aromatic hydrocarbons: isolation and characterization of a pyrene-degrading bacterium.

Authors:  M A Heitkamp; W Franklin; C E Cerniglia
Journal:  Appl Environ Microbiol       Date:  1988-10       Impact factor: 4.792
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