Increase of adrenal weight in rats by the repeated administration of fenitrothion.

Adrenal weight and the concentration of corticosterone and glucose in plasma of male Wistar rats, dosed orally with fenitrothion (7.25 or 14.5 mg/kg/day) for 28 days were investigated. A significant increase in the relative weight of adrenals was observed 2 weeks after treatment commenced, but was preceded by an increase in plasma corticosterone and glucose levels, which reached a maximum within 7 days. These results indicate that the repeated administration of fenitrothion might produce changes in adrenal function in rats.