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Literature DB >> 7090005

Species differences in the testicular toxicity of phthalate esters.

T J Gray, I R Rowland, P M Foster, S D Gangolli.

Abstract

Oral administration of di-n-butylphthalate (DBP) produced uniformly severe seminiferous tubular atrophy in rats and guinea pigs but caused only focal atrophy in mice. Hamsters showed no testicular changes with DBP and only minor changes in response to di-(2-ethylhexyl)phthalate (DEHP) and di-n-pentylphthalate (DPP). The rate of intestinal monohydrolysis of DEHP was slower in hamsters than in rats and this may be important, as mono-(2-ethylhexyl)phthalate (MEHP) did cause focal seminiferous tubular atrophy in hamsters. However, mono-n-butylphthalate (MBP) had no such effect. The decrease in testicular zinc concentration and enhancement of urinary zinc excretion produced in rats by DEHP and DPP was not observed in hamsters. Thus, species differ widely in their sensitivity to the testicular toxicity of phthalate esters.

Entities: Chemical Disease Species

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Year: 1982 PMID： 7090005 DOI： 10.1016/0378-4274(82)90119-9

Source DB: PubMed Journal: Toxicol Lett ISSN： 0378-4274 Impact factor: 4.372

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Cited

21 in total

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Authors: Rebecca A Clewell; Jeremy A Leonard; Chantel I Nicolas; Jerry L Campbell; Miyoung Yoon; Alina Y Efremenko; Patrick D McMullen; Melvin E Andersen; Harvey J Clewell; Katherine A Phillips; Yu-Mei Tan
Journal: Toxicol In Vitro Date: 2020-04-08 Impact factor: 3.500

2. Choline, not folate, can attenuate the teratogenic effects ofdibutyl phthalate (DBP) during early chick embryo development.

Authors: Rui Wang; Da-Guang Sun; Ge Song; Chun Yi Guan; Yi Cui; Xu Ma; Hong-Fei Xia
Journal: Environ Sci Pollut Res Int Date: 2019-08-12 Impact factor: 4.223

3. Testicular effects of di-n-butyl phthalate (DBP): biochemical and histopathological alterations.

Authors: S P Srivastava; S Srivastava; D K Saxena; S V Chandra; P K Seth
Journal: Arch Toxicol Date: 1990 Impact factor: 5.153

Review 4. Fifteen years after "Wingspread"--environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go.

Authors: Andrew K Hotchkiss; Cynthia V Rider; Chad R Blystone; Vickie S Wilson; Phillip C Hartig; Gerald T Ankley; Paul M Foster; Clark L Gray; L Earl Gray
Journal: Toxicol Sci Date: 2008-02-16 Impact factor: 4.849

8. Testicular atrophy induced by di(2-ethylhexyl)phthalate: changes in histology, cell specific enzyme activities and zinc concentrations in rat testis.

Authors: S Oishi
Journal: Arch Toxicol Date: 1986-12 Impact factor: 5.153

9. Age- and species-dependent infiltration of macrophages into the testis of rats and mice exposed to mono-(2-Ethylhexyl) phthalate (MEHP).

Authors: Caitlin J Murphy; Angela R Stermer; John H Richburg
Journal: Biol Reprod Date: 2014-05-29 Impact factor: 4.285

10. Disposition of orally administered di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate in the rat.

Authors: O A Teirlynck; F Belpaire
Journal: Arch Toxicol Date: 1985-09 Impact factor: 5.153