Literature DB >> 7089575

Cysteamine: a potent and specific depletor of pituitary prolactin.

W J Millard, S M Sagar, D M Landis, J B Martin.   

Abstract

Cysteamine rapidly reduces the concentration of prolactin in pituitary tissue in vivo and in vitro. The effect is dose-dependent, reversible, and cannot be accounted for by prolactin release. Cysteamine does not appear to exert its effect through dopamine receptors and does not alter lactotrope morphology, as determined by electron microscopy.

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Year:  1982        PMID: 7089575     DOI: 10.1126/science.7089575

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  5 in total

1.  Influence of cysteamine and cysteine on open-field behaviour, and on brain concentrations of catecholamines, somatostatin, neuropeptide Y, and corticotropin releasing hormone in the rat.

Authors:  L Vécsei; R Ekman; C Alling; E Widerlöv
Journal:  J Neural Transm Gen Sect       Date:  1989

2.  Metabolism of pantethine in cystinosis.

Authors:  C T Wittwer; W A Gahl; J D Butler; M Zatz; J G Thoene
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

3.  Phase advances of circadian rhythms in somatostatin depleted rats: effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus.

Authors:  C Fukuhara; T Hamada; S Shibata; S Watanabe; K Aoki; S I Inouye
Journal:  J Comp Physiol A       Date:  1994-12       Impact factor: 1.836

4.  Effects of cysteamine and antibody to somatostatin on islet cell function in vitro. Evidence that intracellular somatostatin deficiency augments insulin and glucagon secretion.

Authors:  Y C Patel; I Pierzchala; M Amherdt; L Orci
Journal:  J Clin Invest       Date:  1985-04       Impact factor: 14.808

5.  Effect of acrylonitrile on the rat pituitary: enlargement of Golgi region in prolactin cells, crinophagy in prolactin cells and growth hormone cells.

Authors:  K Kamijo; K Kovacs; S Szabo; J N Bollinger-Gruber; S Reichlin
Journal:  Br J Exp Pathol       Date:  1986-06
  5 in total

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