Literature DB >> 7087988

Synthesis of N7-hydroxyethylguanine and O6-hydroxyethylguanine. Markers for the reaction of ethylene oxide (EO) with DNA.

J Ashby, D Paton, J A Styles, D Greatbanks, B Wright.   

Abstract

O6-Hydroxyethylguanine has been synthesized by reaction of mono-sodium glycolate with 6-chloroguanine. The crystalline product has been characterized using a variety of analytical techniques and compared with a sample of the corresponding N7-hydroxyethyl derivative. These 2 chemicals may prove useful as standards when studying the reaction of ethylene oxide (EO) with DNA.

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Year:  1982        PMID： 7087988     DOI： 10.1016/0165-7992(82)90051-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  4 in total

1.  Cross-linking of DNA induced by chloroethylnitrosourea is presented by O6-methylguanine-DNA methyltransferase.

Authors:  P Robins; A L Harris; I Goldsmith; T Lindahl
Journal:  Nucleic Acids Res       Date:  1983-11-25       Impact factor: 16.971

2.  6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea.

Authors:  H W Thielmann; L Edler; N Müller; G Eisenbrand
Journal:  J Cancer Res Clin Oncol       Date:  1987       Impact factor: 4.553

Review 3.  Analysis of macromolecular ethylene oxide adducts.

Authors:  H M Bolt; H Peter; U Föst
Journal:  Int Arch Occup Environ Health       Date:  1988       Impact factor: 3.015

4.  Inhalation pharmacokinetics based on gas uptake studies. V. Comparative pharmacokinetics of ethylene and 1,3-butadiene in rats.

Authors:  H M Bolt; J G Filser; F Störmer
Journal:  Arch Toxicol       Date:  1984-10       Impact factor: 5.153
  4 in total

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