Literature DB >> 7087684

Oral contraceptive and Platelet lipid biosynthesis in female rats: dose-response relationship.

M Ciavatti, E Davenas, G Michel, S Renaud.   

Abstract

Female rats were treated with different doses of an oral contraceptive (ethinyl estradiol + lynestrenol) and lipid biosynthesis was studied in blood platelets by acetate incorporation into different fractions separated by thin layer chromatography. A marked increase in lipid biosynthesis was observed, especially in the sterol fractions (cholesterol and lanosterol-dihydrolanosterol). It was dose-dependent, observed after a lag-phase, maximal in 3 days and normalized in 8 days. Thus, the oral contraceptive studied here appears to modify platelet lipid biosynthesis for the entire life of the platelets.

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Year:  1982        PMID： 7087684     DOI： 10.1007/BF02535185

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  11 in total

1.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

2.  Possible hazards of oral contraceptive use.

Authors:  W B Kannel
Journal:  Circulation       Date:  1979-09       Impact factor: 29.690

3.  Extensive incorporation of (2-14C) mevalonic acid into cholesterol precursors by human platelets in vitro.

Authors:  A Derksen; P Cohen
Journal:  J Biol Chem       Date:  1973-11-10       Impact factor: 5.157

4.  Serum-lipids in women on oral contraceptives.

Authors:  T Stokes; V Wynn
Journal:  Lancet       Date:  1971-09-25       Impact factor: 79.321

5.  Separation of "neutral" lipids, particularly of all classes of partial glycerides by one-dimensional thin-layer chromatography.

Authors:  F Kunz
Journal:  Biochim Biophys Acta       Date:  1973-02-14

6.  Oral contraceptives and mortality trends from thromboembolism in the United States.

Authors:  R E Markush; D G Seigel
Journal:  Am J Public Health Nations Health       Date:  1969-03

7.  Thromboembolic disease and the steroidal content of oral contraceptives. A report to the Committee on Safety of Drugs.

Authors:  W H Inman; M P Vessey; B Westerholm; A Engelund
Journal:  Br Med J       Date:  1970-04-25

8.  Biosynthesis of cholesterol and cholesterol precursors in platelets of female rats treated with oral contraceptives.

Authors:  M Ciavatti; G Michel; S Renaud
Journal:  Biochim Biophys Acta       Date:  1980-11-07

9.  Modification by oral contraceptives in rat of 14C acetate incorporation into platelet lipids.

Authors:  M Ciavatti; S Renaud
Journal:  Horm Metab Res       Date:  1979-07       Impact factor: 2.936
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