| Literature DB >> 7085626 |
R Shen, R V Smith, P J Davis, A Brubaker, C W Abell.
Abstract
Dopamine-derived tetrahydroisoquinolines, such as 3',4'-deoxynorlaudanosolinecarboxylic acid, higenamine-1-carboxylic acid, higenamine, and salsolinol, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 90 microM. The enzyme is also inhibited noncompetitively by dopamine (Ki = 6 microM) and aminopterin (Ki = 100 microM) but uncompetitively by phenylpyruvic acid (Ki = 6.5 mM). These alkaloids may alter monoamine metabolism in mammals by inhibiting dihydropteridine reductase.Entities:
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Year: 1982 PMID： 7085626
Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157