Measurement of gastric mucosal blood flow in dogs by the 99mTc-4-methylaminophenazone clearance technique.

In anesthetized dogs, correlation was found between the 99mTc-4-methylaminophenazone and aminopyrine clearance measured in the same animal after administration of the gastric secretory stimulants vasopressin or glucagon. Similar correlation was observed between the 99mTc-4-methylaminophenazone and [14C]aminopyrine clearance during histamine administration. The clearance values were always corrected by the actual degree of dissociation of the radioactive molecules. The results suggest that 99mTc-4-methylaminophenazone is suitable to study circulatory changes in human gastric mucosa. Advantages of this compound include a much lower dose of radiation absorbed by the patient and his surroundings, a simplified measurement technique, and considerably reduced expenses.