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Literature DB >> 708387

A difference in the specificities of human liver N-acetyl-beta-hexosaminidases A and B detected by their activities towards glycosaminoglycan oligosaccharides.

Abstract

N-Acetyl-beta-hexosaminidases A and B differ in their activities towards oligosaccharides prepared from glycosaminoglycans. Trisaccharides from hyaluronic acid and desulphated chondroitin 4-sulphate were hydrolysed by N-acetyl-beta-hexosaminidase A, but not by N-acetyl-beta-hexosaminidase B.

Entities: Chemical Species

Mesh：

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Year: 1978 PMID： 708387 PMCID： PMC1185871 DOI： 10.1042/bj1730997

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

25 in total

1. The hydrolysis of Tay-Sachs ganglioside (TSG) by human N-acetyl-beta-D-hexosaminidase A.

Authors: K Sandhoff
Journal: FEBS Lett Date: 1970-12-18 Impact factor: 4.124

2. The subunits of human hexosaminidase A.

Authors: E Beutler; A Yoshida; W Kuhl; J E Lee
Journal: Biochem J Date: 1976-12-01 Impact factor: 3.857

3. Specificity of human liver hexosaminidases A and B against glycosphingolipids GM2 and GA2. Purification of the enzymes by affinity chromatography employing specific elution.

Authors: K Sandhoff; E Conzelmann; H Nehrkorn
Journal: Hoppe Seylers Z Physiol Chem Date: 1977-07

4. Evidence for different glycohydrolase and glycosyltransferase activities of beta-N-acetylglucosaminidases A and B.

Authors: E Werries; I Neue; E Buddecke
Journal: Hoppe Seylers Z Physiol Chem Date: 1975-06

5. Isolation and relationship of human hexosaminidases.

Authors: J F Tallman; R O Brady; J M Quirk; M Villalba; A E Gal
Journal: J Biol Chem Date: 1974-06-10 Impact factor: 5.157

6. Mucopoly saccharide storage in organs of a patient with Sandhoff's disease.

Authors: D A Applegarth; G Bozoian
Journal: Clin Chim Acta Date: 1972-06 Impact factor: 3.786

7. Gm2-gangliosidosis with total hexosaminidase deficiency.

Authors: Y Suzuki; J C Jacob; K Suzuki; K M Kutty; K Suzuki
Journal: Neurology Date: 1971-04 Impact factor: 9.910

8. Hydrolysis of Tay-Sachs ganglioside by beta-hexosaminidase A of human liver and urine.

Authors: Y T Li; M Y Mazzotta; C C Wan; R Orth; S C Li
Journal: J Biol Chem Date: 1973-11-10 Impact factor: 5.157

9. [Oligosaccharide excretion in a case of GM 2 gangliosidosis due to total N-acetylhexosaminidase deficiency].

Authors: G Strecker; J Montreuil
Journal: Clin Chim Acta Date: 1971-07 Impact factor: 3.786

10. N-Acetyl-beta-glucosaminidases in human spleen.

Authors: D Robinson; J L Stirling
Journal: Biochem J Date: 1968-04 Impact factor: 3.857

7 in total

Review 1. Biochemistry and genetics of gangliosidoses.

Authors: K Sandhoff; H Christomanou
Journal: Hum Genet Date: 1979 Impact factor: 4.132

Review 2. Chaperone therapy for GM2 gangliosidosis: effects of pyrimethamine on β-hexosaminidase activity in Sandhoff fibroblasts.

Authors: Elena Chiricozzi; Natalia Niemir; Massimo Aureli; Alessandro Magini; Nicoletta Loberto; Alessandro Prinetti; Rosaria Bassi; Alice Polchi; Carla Emiliani; Catherine Caillaud; Sandro Sonnino
Journal: Mol Neurobiol Date: 2013-12-20 Impact factor: 5.590