Literature DB >> 7083643

Phagocytosis and intracellular degradation of 125I-labelled immune complexes by Clofazimine treated macrophage cultures.

J Sarracent, C M Finlay.   

Abstract

Mouse peritoneal and calf alveolar macrophage cultures were exposed to various Clofazimine concentrations for 5 days. Cultures exposed to drug concentrations near the blood therapeutic level phagocytize and digest more immune complexes than control cultures. Our results allow us to suggest that the beneficial action of Clofazimine in lepromatous leprosy could be at least partially mediated by the removal and degradation of circulating immune complexes by macrophages.

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Year:  1982        PMID： 7083643      PMCID： PMC1536589     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  8 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  A method of trace iodination of proteins for immunologic studies.

Authors:  P J McConahey; F J Dixon
Journal:  Int Arch Allergy Appl Immunol       Date:  1966

3.  Evidence for circulating immune complexes in lepromatous leprosy.

Authors:  C J Moran; G Ryder; J L Turk; M F Waters
Journal:  Lancet       Date:  1972-09-16       Impact factor: 79.321

4.  Stimulation of macrophage phagocytosis by clofazimine.

Authors:  L Brandt; B Svensson
Journal:  Scand J Haematol       Date:  1973

5.  Clinical correlates of C1Q-precipitating substances in the sera of patients with leprosy.

Authors:  R H Gelber; D J Drutz; W V Epstein; P Fasal
Journal:  Am J Trop Med Hyg       Date:  1974-05       Impact factor: 2.345

6.  Forty-four months' experience in the treatment of leprosy with clofazimine (Lamprene (Geigy)).

Authors:  E J Schulz
Journal:  Lepr Rev       Date:  1971-09       Impact factor: 0.537

7.  Isolation, chemical and immunologic characterization of kappa and lambda-type light chains from IgG of normal rabbits with b9 allotype.

Authors:  A Chersi; R Mage; J Rejnek; R Reisfeld
Journal:  J Immunol       Date:  1970-05       Impact factor: 5.422

8.  THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.

Authors:  Z A COHN; B BENSON
Journal:  J Exp Med       Date:  1965-01-01       Impact factor: 14.307
  8 in total

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