Literature DB >> 7083246

Changes in intestinal permeability to lactulose induced by cytotoxic chemotherapy.

G Parrilli, R V Iaffaioli, G Capuano, G Budillon, A R Bianco.   

Abstract

Intestinal function during cytotoxic therapy was studied in nine patients with nonintestinal lymphoma. An early, marked, and rapidly reversible increase in passive permeability, as disclosed by the lactulose test, was observed without concomitant changes in active absorption or in intestinal histology. The possibility of a toxic effect by cytotoxic drugs on intestinal intracellular junctions is discussed.

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Year:  1982        PMID: 7083246

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN: 0361-5960


  5 in total

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Review 4.  Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview.

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5.  Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum.

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  5 in total

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