The histological structure of Kveim tests parallels the evolution of pulmonary sarcoidosis.

The histopathology of the granulomas induced by Kveim antigen varies in patients with sarcoidosis. Eighty skin sites of Kveim tests were biopsied 4 and 5 weeks after the antigen was injected into the skin of patients with pulmonary sarcoidosis. The histological features in the skin of Kveim tests differed according to the stage of evolution of sarcoidosis and seem to parallel the pathological changes in the lung.