Chronic pancreatitis with cyst formation after prednisone and thiazide treatment.

Acute pancreatitis has been associated with multiple drugs. Some animal and autopsy studies have shown chronic focal changes. Most clinical reports have shown acute pancreatitis at autopsy or an acute clinical course. Herein we present a patient with chronic pancreatitis with cyst formation that was detected several months after steroid administration had been stopped. The histological findings in the resected pancreas showed ectatic ducts, acute and chronic inflammation, and laminated protein concretions in dilated pancreatic ducts. The findings in this patient suggest that drug therapy might be etiological in causing selected cases of chronic pancreatitis.