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Literature DB >> 7080011

Factors influencing the bronchodilator effect of a deep inspiration in asthmatic patients with provoked bronchoconstriction.

Abstract

We have studied 26 asthmatic patients in whom deep inspiration induced a transient but marked bronchodilatation when carbachol-induced bronchoconstriction was present. Changes in bronchial tone were assessed by specific airway resistance measurements. Bronchodilatation after a slow inspiration (eight subjects) or a 10-second breath-hold at total lung capacity (13 subjects) was significantly less than that observed after either a fast inspiration or no breath-holding period. The magnitude of the bronchodilatation induced by a fast inspiration without breath-holding was directly and significantly related to the magnitude of the carbachol-induced bronchoconstriction in five subjects.

Entities: Chemical Species

Mesh：

Substances：
Carbachol

Year: 1982 PMID： 7080011 PMCID： PMC459262 DOI： 10.1136/thx.37.2.124

Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139

19 in total

Factors influencing the bronchodilator effect of a deep inspiration in asthmatic patients with provoked bronchoconstriction.

1. Bronchoconstrictor effects of a deep inspiration in patients with asthma.

2. Effect of deep inspiration on airway conductance in subjects with allergic rhinitis and allergic asthma.

3. Effect of short-term, low-level nitrogen dioxide exposure on bronchial sensitivity of asthmatic patients.

Review 4. Vagal sensory receptors and their reflex effects.

5. Humoral control of airways.

6. Time dependence of flow-volume curves.

7. Relative hysteresis of the dead space and lung in vivo.

8. Release of prostaglandin E2 and unidentified factors from ventilated lungs.

9. Hysteresis and stress adaptation in the human respiratory system.

10. The interaction of chemo- and mechanoreceptor signals in the control of airway calibre.

1. Bronchodilatation induced by deep breaths in relation to transpulmonary pressure and lung volume.

2. Abolition of methacholine induced bronchoconstriction by the hyperventilation of exercise or volition.

3. Deep breaths and airway obstruction in asthma.

4. Effect of inspiratory flow rate on bronchomotor tone in normal and asthmatic subjects.

5. Diurnal variation and adaptation of the cough response to citric acid in normal subjects.

Review 6. Physiological assessment of inflammation in the peripheral lung of asthmatic patients.

7. Effect of parenchymal stiffness on canine airway size with lung inflation.

8. Histamine phosphate has a cumulative effect when inhaled at five minute intervals.

9. The Strain on Airway Smooth Muscle During a Deep Inspiration to Total Lung Capacity.

10. Simulation of bronchial airway acoustics in healthy and asthmatic subjects.