Literature DB >> 7079739

Early chronic low-level methylmercury poisoning in monkeys impairs spatial vision.

D C Rice, S G Gilbert.   

Abstract

Five monkeys were treated from birth with oral doses of mercury as methylmercury (50 micrograms per kilogram of body weight per day); concentrations in the blood peaked at 1.2 to 1.4 parts per million; and declined after weaning from infant formula to a steady level of 0.6 to 0.9 part per million. There were no overt signs of toxicity. When tested between 3 and 4 years of age under conditions of both high and low luminance, treated monkeys exhibited spatial vision that was impaired compared with that of control monkeys.

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Year:  1982        PMID: 7079739     DOI: 10.1126/science.7079739

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  14 in total

Review 1.  Methylmercury: a potential environmental risk factor contributing to epileptogenesis.

Authors:  Yukun Yuan
Journal:  Neurotoxicology       Date:  2011-12-22       Impact factor: 4.294

2.  Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures.

Authors:  Katie Sokolowski; Anthony Falluel-Morel; Xiaofeng Zhou; Emanuel DiCicco-Bloom
Journal:  Neurotoxicology       Date:  2011-06-29       Impact factor: 4.294

Review 3.  Toxicity of lead, cadmium, and mercury: considerations for total parenteral nutritional support.

Authors:  K R Mahaffey
Journal:  Bull N Y Acad Med       Date:  1984-03

4.  Low level postnatal methylmercury exposure in vivo alters developmental forms of short-term synaptic plasticity in the visual cortex of rat.

Authors:  Sameera Dasari; Yukun Yuan
Journal:  Toxicol Appl Pharmacol       Date:  2009-08-05       Impact factor: 4.219

Review 5.  Animal behavioral methods in neurotoxicity assessment: SGOMSEC joint report.

Authors:  B Kulig; E Alleva; G Bignami; J Cohn; D Cory-Slechta; V Landa; J O'Donoghue; D Peakall
Journal:  Environ Health Perspect       Date:  1996-04       Impact factor: 9.031

6.  In vivo methylmercury exposure induced long-lasting epileptiform activity in layer II/III neurons in cortical slices from the rat.

Authors:  Sameera Dasari; Yukun Yuan
Journal:  Toxicol Lett       Date:  2010-01-04       Impact factor: 4.372

7.  Spatial and visual discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n-3 polyunsaturated fatty acids.

Authors:  Elliott M Paletz; Jeremy J Day; Margaret C Craig-Schmidt; M Christopher Newland
Journal:  Neurotoxicology       Date:  2007-05-06       Impact factor: 4.294

Review 8.  Methylmercury and nutrition: adult effects of fetal exposure in experimental models.

Authors:  M Christopher Newland; Elliott M Paletz; Miranda N Reed
Journal:  Neurotoxicology       Date:  2008-07-05       Impact factor: 4.294

9.  What is regressive autism and why does it occur? Is it the consequence of multi-systemic dysfunction affecting the elimination of heavy metals and the ability to regulate neural temperature?

Authors:  Graham E Ewing
Journal:  N Am J Med Sci       Date:  2009-07

10.  Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal.

Authors:  Thomas M Burbacher; Danny D Shen; Noelle Liberato; Kimberly S Grant; Elsa Cernichiari; Thomas Clarkson
Journal:  Environ Health Perspect       Date:  2005-08       Impact factor: 9.031

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