Literature DB >> 7079735

Cellular mechanism of neuronal synchronization in epilepsy.

R D Traub, R K Wong.   

Abstract

Interictal spikes are a simple kind of epileptic neuronal activity. Field potentials and intracellular recordings observed during interictal spikes of penicillin-treated slices of the hippocampus were reproduced by a mathematical model of a network of 100 hippocampal neurons from the region including CA2 and CA3. The model shows that this form of neuronal synchronization arises because of mutual excitation between neurons, each of which is capable of intrinsic bursting in response to a brief input.

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Year:  1982        PMID： 7079735     DOI： 10.1126/science.7079735

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  144 in total

1.  Upregulation of a T-type Ca2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus.

Authors:  Hailing Su; Dmitry Sochivko; Albert Becker; Jian Chen; Yanwen Jiang; Yoel Yaari; Heinz Beck
Journal:  J Neurosci       Date:  2002-05-01       Impact factor: 6.167

2.  Nociceptin reduces epileptiform events in CA3 hippocampus via presynaptic and postsynaptic mechanisms.

Authors:  M K Tallent; S G Madamba; G R Siggins
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

3.  Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current.

Authors:  H Y Jung ; N P Staff; N Spruston
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

Review 4.  Mechanisms of Persistent Activity in Cortical Circuits: Possible Neural Substrates for Working Memory.

Authors:  Joel Zylberberg; Ben W Strowbridge
Journal:  Annu Rev Neurosci       Date:  2017-07-25       Impact factor: 12.449

Review 5.  Brain extracellular space, hyaluronan, and the prevention of epileptic seizures.

Authors:  Katherine L Perkins; Amaia M Arranz; Yu Yamaguchi; Sabina Hrabetova
Journal:  Rev Neurosci       Date:  2017-11-27       Impact factor: 4.353

6.  Absence of GABRA1 Ala322Asp mutation in juvenile myoclonic epilepsy families from India.

Authors:  A Kapoor; J Vijai; H M Ravishankar; P Satishchandra; K Radhakrishnan; A Anand
Journal:  J Genet       Date:  2003 Apr-Aug       Impact factor: 1.166

7.  On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.

Authors:  Daniela Bianchi; Addolorata Marasco; Alessandro Limongiello; Cristina Marchetti; Helene Marie; Brunello Tirozzi; Michele Migliore
Journal:  J Comput Neurosci       Date:  2012-02-05       Impact factor: 1.621

Review 8.  Neurophysiological and computational principles of cortical rhythms in cognition.

Authors:  Xiao-Jing Wang
Journal:  Physiol Rev       Date:  2010-07       Impact factor: 37.312

9.  Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice.

Authors:  R D Traub; J G Jefferys; M A Whittington
Journal:  J Physiol       Date:  1994-08-01       Impact factor: 5.182

10.  Epileptiform activity in rat hippocampus strengthens excitatory synapses.

Authors:  Mathias H Abegg; Natasa Savic; Markus U Ehrengruber; R Anne McKinney; Beat H Gähwiler
Journal:  J Physiol       Date:  2003-10-31       Impact factor: 5.182
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