Literature DB >> 7079276

Relative responding on concurrent schedules: indexing ethanol's reinforcing efficacy.

T A Roehrs, H H Samson.   

Abstract

Five rats were trained to lever press on a concurrent schedule resulting in 3 second access to a dipper (0.1 ml) with either ethanlo (5% v/v) or water. Stable concurrent fixed ratio (FR8 FR8) ethanol and water responding was established. The proportion of responses for ethanol relative to the total number responses varied among rats from 77% to 98%. While the absolute number of responses for ethanol varied greatly day to day, the proportion of ethanol responding was stable. Absolute number of responses for ethanol and proportion of ethanol responding both declined as the body weight of the rats was allowed to increase from initial 80% of ad lib to 110%, with absolute responding showing the greater change. It was concluded that the relative measure of responding on a concurrent schedule could be useful as an index of a drug's reinforcing efficacy, but must be interpreted carefully in regards to the context of drug availability.

Entities:  

Mesh:

Substances:

Year:  1982        PMID: 7079276     DOI: 10.1016/0091-3057(82)90440-3

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN: 0091-3057            Impact factor:   3.533


  5 in total

1.  Ethanol regulated preference in rats.

Authors:  G M Heyman
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

2.  Ethanol-maintained behavior in a foraging context: effects of search and procurement cost.

Authors:  A Liguori
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

3.  Induction and maintenance of ethanol self-administration without food deprivation in the rat.

Authors:  K A Grant; H H Samson
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

4.  Chlordiazepoxide effects on ethanol self-administration: dependence on concurrent conditions.

Authors:  H H Samson; K A Grant
Journal:  J Exp Anal Behav       Date:  1985-05       Impact factor: 2.468

Review 5.  Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal.

Authors:  Tamzin L Ripley; David N Stephens
Journal:  Br J Pharmacol       Date:  2011-10       Impact factor: 8.739

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.