Literature DB >> 7077782

Cause of death in very old people.

R R Kohn.   

Abstract

According to the Vital Statistics, white women have a modal life span of 85 to 90 years, with most individuals dying at around the same age from either ischemic heart disease, cerebrovascular disease, pneumonia, or accidents, or at earlier ages from malignant neoplasms. White men die earlier than women, and nonwhite populations contain two or more subpopulations that die earlier than white populations. Major causes of death listed in Vital Statistics show similar patterns in the aged for all populations. A review of autopsy findings in 200 persons older than 85 years yielded a very different pattern. No acceptable cause of death, other than complications of the aging syndrome, was identified in at least 30% of the cases. Vital Statistics for the aged is misleading because diagnoses are not definitive. Physicians accept causes of death in the aged that would not be acceptable in younger persons, and the role of aging processes themselves as cause of death are not appreciated. Aging is characterized by a universal progressive decline in physiological function to the point where life cannot be maintained in the face of otherwise trivial tissue injury. It is proposed that senescence be viewed as a disease and be accepted as a cause of death.

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Year:  1982        PMID: 7077782

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


  27 in total

1.  Influenza vaccines: antibody responses to split virus and MF59-adjuvanted subunit virus in an adult population.

Authors:  T Menegon; V Baldo; C Bonello; D Dalla Costa; A Di Tommaso; R Trivello
Journal:  Eur J Epidemiol       Date:  1999-07       Impact factor: 8.082

2.  Ill-defined and multiple causes on death certificates--a study of misclassification in mortality statistics.

Authors:  M D'Amico; E Agozzino; A Biagino; A Simonetti; P Marinelli
Journal:  Eur J Epidemiol       Date:  1999-02       Impact factor: 8.082

3.  Nonagenarians and centenarians in Switzerland, 1860-2001: a demographic analysis.

Authors:  Jean-Marie Robine; Fred Paccaud
Journal:  J Epidemiol Community Health       Date:  2005-01       Impact factor: 3.710

4.  Derivation and validation of a mortality-risk index from a cohort of frail elderly patients hospitalised in medical wards via emergencies: the SAFES study.

Authors:  M Dramé; J L Novella; P O Lang; D Somme; N Jovenin; I Lanièce; P Couturier; D Heitz; J B Gauvain; T Voisin; B De Wazières; R Gonthier; J Ankri; C Jeandel; O Saint-Jean; F Blanchard; D Jolly
Journal:  Eur J Epidemiol       Date:  2008-10-21       Impact factor: 8.082

5.  Misclassification of coronary heart disease in mortality statistics. Evidence from the WHO-MONICA Ghent-Charleroi Study in Belgium.

Authors:  S De Henauw; P de Smet; W Aelvoet; M Kornitzer; G De Backer
Journal:  J Epidemiol Community Health       Date:  1998-08       Impact factor: 3.710

Review 6.  Immunosenescence revisited. Does it have any clinical significance?

Authors:  A J Voets; L R Tulner; G J Ligthart
Journal:  Drugs Aging       Date:  1997-07       Impact factor: 3.923

Review 7.  Free radicals in aging.

Authors:  D Harman
Journal:  Mol Cell Biochem       Date:  1988-12       Impact factor: 3.396

8.  Comparison of immunogenicity and safety of a virosome influenza vaccine with those of a subunit influenza vaccine in pediatric patients with cystic fibrosis.

Authors:  U B Schaad; U Bühlmann; R Burger; A Ruedeberg; A Wilder-Smith; M Rutishauser; F Sennhauser; C Herzog; M Zellmeyer; R Glück
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

9.  Altered regulation of inducible nitric oxide synthase expression in macrophages from senescent mice.

Authors:  L C Chen; J L Pace; S W Russell; D C Morrison
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

Review 10.  Antibiotic therapy in aging patients.

Authors:  S R Norrby
Journal:  Bull N Y Acad Med       Date:  1987 Jul-Aug
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