Literature DB >> 7076845

Instability of beta E-messenger RNA during erythroid cell maturation in hemoglobin E homozygotes.

J Traeger, P Winichagoon, W G Wood.   

Abstract

Hemoglobin E interacts with beta-thalassemia to produce a disorder of variable severity that is the most common form of symptomatic thalassemia in Southeast Asia. The beta E-globin gene acts as a mild thalassemia gene; there are low levels of beta E-messenger RNA (mRNA) in reticulocytes, and preliminary evidence had suggested that this might be due to instability of the beta E-mRNA. Analysis of beta E-mRNA levels in the nuclei and cytoplasm of bone marrow erythroblasts compared with reticulocytes has shown higher levels of beta E-mRNA in the former, providing direct evidence that this is the case.

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Year:  1982        PMID： 7076845      PMCID： PMC370162          DOI： 10.1172/jci110510

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  8 in total

1.  Hb Henri Mondor: beta26 (B8) Glu leads to Val: a variant with a substitution localized at the same position as that of HbE beta26 Glu leads to Lys.

Authors:  Y Blouquit; N Arous; P E Machado; M C Garel
Journal:  FEBS Lett       Date:  1976-12-15       Impact factor: 4.124

2.  Negro alpha-thalassaemia is caused by deletion of a single alpha-globin gene.

Authors:  D R Higgs; L Pressley; J M Old; D M Hunt; J B Clegg; D J Weatherall; G R Serjeant
Journal:  Lancet       Date:  1979-08-11       Impact factor: 79.321

3.  Heterogeneity of messenger RNA defects in the thalassemia syndromes.

Authors:  E J Benz; J Glass; G A Tsistrakis; D G Hillman; C Cavallesco; E Coupal; B G Forget; P A Turner; J A Kantor; A W Nienhuis
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

4.  Determination of alpha thalassaemia phenotypes by messenger RNA analysis.

Authors:  D M Hunt; D R Higgs; J B Clegg; D J Weatherball; G W Marsh
Journal:  Br J Haematol       Date:  1980-05       Impact factor: 6.998

5.  Molecular analysis of the beta-thalassemia phenotype associated with inheritance of hemoglobin E (alpha 2 beta2(26)Glu leads to Lys).

Authors:  E J Benz; B W Berman; B L Tonkonow; E Coupal; T Coates; L A Boxer; A Altman; J G Adams
Journal:  J Clin Invest       Date:  1981-07       Impact factor: 14.808

6.  Gene deletions in alpha thalassemia prove that the 5' zeta locus is functional.

Authors:  L Pressley; D R Higgs; J B Clegg; D J Weatherall
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

7.  Homozygous hemoglobin E mimics beta-thalassemia minor without anemia or hemolysis: hematologic, functional, and biosynthetic studies of first North American cases.

Authors:  V F Fairbanks; R Oliveros; J H Brandabur; R R Willis; R F Fiester
Journal:  Am J Hematol       Date:  1980       Impact factor: 10.047

8.  Relative stability of alpha- and beta-globin messenger RNAs in homozygous beta+ thalassemia.

Authors:  A W Nienhuis; P Turner; E J Benz
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205
  8 in total
  4 in total

Review 1.  The thalassemias: molecular mechanisms of human genetic disease.

Authors:  R A Spritz; B G Forget
Journal:  Am J Hum Genet       Date:  1983-05       Impact factor: 11.025

Review 2.  Thalassemic hemoglobinopathies.

Authors:  M H Steinberg; J G Adams
Journal:  Am J Pathol       Date:  1983-12       Impact factor: 4.307

3.  Hemoglobin Mississippi (beta 44ser----cys). Studies of the thalassemic phenotype in a mixed heterozygote with beta +-thalassemia.

Authors:  M H Steinberg; J G Adams; W T Morrison; D J Pullen; R Abney; A Ibrahim; R F Rieder
Journal:  J Clin Invest       Date:  1987-03       Impact factor: 14.808

Review 4.  Haemoglobinopathies in southeast Asia.

Authors:  Suthat Fucharoen; Pranee Winichagoon
Journal:  Indian J Med Res       Date:  2011-10       Impact factor: 2.375
  4 in total

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