Literature DB >> 7076658

Accumulation of dolichols in brains of elderly.

R K Pullarkat, H Reha.   

Abstract

Dolichol levels in human brain gray matter increased from 18 micrograms/g in 6-year-old to 263 micrograms/g in 68-year-old human brain gray matter. High performance liquid chromatographic analysis shows dolichols ranging from 14 to 22 isoprene units with 19 isoprene units containing species predominating (approximately 44%). This may be the first report of an appreciable accumulation of a lipid in brains of elderly.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7076658

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  20 in total

Review 1.  Isoprenoids, small GTPases and Alzheimer's disease.

Authors:  Gero P Hooff; W Gibson Wood; Walter E Müller; Gunter P Eckert
Journal:  Biochim Biophys Acta       Date:  2010-04-08

Review 2.  The biological role of dolichol.

Authors:  T Chojnacki; G Dallner
Journal:  Biochem J       Date:  1988-04-01       Impact factor: 3.857

3.  A micromethod for the estimation of blood dolichol.

Authors:  G N Morris; R K Pullarkat
Journal:  Lipids       Date:  1987-01       Impact factor: 1.880

4.  Dolichol metabolism in cultured skin fibroblasts from patients with "neuronal" ceroid lipofuscinosis (Batten's disease).

Authors:  B C Paton; A Poulos
Journal:  J Inherit Metab Dis       Date:  1984       Impact factor: 4.982

5.  A missense mutation in DHDDS, encoding dehydrodolichyl diphosphate synthase, is associated with autosomal-recessive retinitis pigmentosa in Ashkenazi Jews.

Authors:  Lina Zelinger; Eyal Banin; Alexey Obolensky; Liliana Mizrahi-Meissonnier; Avigail Beryozkin; Dikla Bandah-Rozenfeld; Shahar Frenkel; Tamar Ben-Yosef; Saul Merin; Sharon B Schwartz; Artur V Cideciyan; Samuel G Jacobson; Dror Sharon
Journal:  Am J Hum Genet       Date:  2011-02-03       Impact factor: 11.025

6.  Low-density lipoprotein as a transporter of dolichol intermediates in the mammalian circulation.

Authors:  J W Rip; M M Blais; L W Jiang
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

7.  Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson's disease.

Authors:  Fabio A Zucca; Renzo Vanna; Francesca A Cupaioli; Chiara Bellei; Antonella De Palma; Dario Di Silvestre; Pierluigi Mauri; Sara Grassi; Alessandro Prinetti; Luigi Casella; David Sulzer; Luigi Zecca
Journal:  NPJ Parkinsons Dis       Date:  2018-06-05

8.  Determination of arrangement of isoprene units in pig liver dolichol by 13C-n.m.r. spectroscopy.

Authors:  Y Tanaka; H Sato; A Kageyu; T Tomita
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

9.  Age-related changes in the lipid compositions of rat and human tissues.

Authors:  A Kalén; E L Appelkvist; G Dallner
Journal:  Lipids       Date:  1989-07       Impact factor: 1.880

10.  Uptake and metabolism of dolichol and cholesterol in perfused rat liver.

Authors:  A Kalén; M Söderberg; P G Elmberger; G Dallner
Journal:  Lipids       Date:  1990-02       Impact factor: 1.880
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.