Literature DB >> 7076567

Synthesis and structure-activity relationships of amides of amphotericin B.

A Jarzebski, L Falkowski, E Borowski.   

Abstract

A series of aliphatic amides of amphotericin B have been synthesized. The structure of the derivatives which were obtained has been established by mass spectrometry. Their biological properties: inhibition of growth of Saccharomyces cerevisiae and hemolytic activity have been determined. The quantitative relationships between the activity of amides of amphotericin B against S. cerevisiae and their lipophilicity can be expressed by a parabolic function, whereas that between hemolytic activity and lipophilicity--by polynominal expression of fourth degree.

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Year:  1982        PMID： 7076567     DOI： 10.7164/antibiotics.35.220

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  Influence of net charge on the aggregation and solubility behaviour of amphotericin B and its derivatives in aqueous media.

Authors:  J Mazerski; J Grzybowska; E Borowski
Journal:  Eur Biophys J       Date:  1990       Impact factor: 1.733

2.  Conformational properties of amphotericin B amide derivatives--impact on selective toxicity.

Authors:  H Resat; F A Sungur; M Baginski; E Borowski; V Aviyente
Journal:  J Comput Aided Mol Des       Date:  2000-10       Impact factor: 3.686

3.  Structure-antifungal activity relationships of polyene antibiotics of the amphotericin B group.

Authors:  Anna N Tevyashova; Evgenia N Olsufyeva; Svetlana E Solovieva; Svetlana S Printsevskaya; Marina I Reznikova; Aleksei S Trenin; Olga A Galatenko; Ivan D Treshalin; Eleonora R Pereverzeva; Elena P Mirchink; Elena B Isakova; Sergey B Zotchev; Maria N Preobrazhenskaya
Journal:  Antimicrob Agents Chemother       Date:  2013-05-28       Impact factor: 5.191

4.  Molecular aspects of the interaction between amphotericin B and a phospholipid bilayer: molecular dynamics studies.

Authors:  Kamil Sternal; Jacek Czub; Maciej Baginski
Journal:  J Mol Model       Date:  2004-04-30       Impact factor: 1.810

Review 5.  In silico prediction of drug toxicity.

Authors:  John C Dearden
Journal:  J Comput Aided Mol Des       Date:  2003 Feb-Apr       Impact factor: 3.686

6.  An Amphotericin B Derivative Equally Potent to Amphotericin B and with Increased Safety.

Authors:  Armando Antillón; Alexander H de Vries; Marcel Espinosa-Caballero; José Marcos Falcón-González; David Flores Romero; Javier González-Damián; Fabiola Eloísa Jiménez-Montejo; Angel León-Buitimea; Manuel López-Ortiz; Ricardo Magaña; Siewert J Marrink; Rosmarbel Morales-Nava; Xavier Periole; Jorge Reyes-Esparza; Josué Rodríguez Lozada; Tania Minerva Santiago-Angelino; María Cristina Vargas González; Ignacio Regla; Mauricio Carrillo-Tripp; Mario Fernández-Zertuche; Lourdes Rodríguez-Fragoso; Iván Ortega-Blake
Journal:  PLoS One       Date:  2016-09-28       Impact factor: 3.240
  6 in total

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