Literature DB >> 7075721

Activity of orotate metabolizing enzyme complex and various urea-cycle enzymes in mutant mice with ornithine transcarbamylase deficiency.

I A Qureshi, J Letarte, R Ouellet.   

Abstract

The overall activity of the enzyme complex consisting of orotate phosphoribosyl transferase and orotidine monophosphate decarboxylase, and of various enzymes of the urea cycle, has ben studied in sparse-fur (spf) mutant mice with ornithine transcarbamylase deficiency. The enzyme complex has a lower overall activity, which could be caused by disturbed pyrimidine metabolism due to hyperammonemia. Other enzymes of the urea cycle do not show any significant change.

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Year:  1982        PMID： 7075721     DOI： 10.1007/bf01949358

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation.

Authors:  R DeMars; S L LeVan; B L Trend; L B Russell
Journal:  Proc Natl Acad Sci U S A       Date:  1976-05       Impact factor: 11.205

Review 3.  A review: biological and clinical aspects of pyrimidine metabolism.

Authors:  R L Levine; N J Hoogenraad; N Kretchmer
Journal:  Pediatr Res       Date:  1974-07       Impact factor: 3.756

Review 4.  Inherited hyperammonemic syndromes.

Authors:  Y E Hsia
Journal:  Gastroenterology       Date:  1974-08       Impact factor: 22.682

5.  Effect of uridine on de novo pyrimidine biosynthesis in rat hepatoma cells in culture.

Authors:  N J Hoogenraad; D C Lee
Journal:  J Biol Chem       Date:  1974-05-10       Impact factor: 5.157

6.  Biochemical investigations of hyperammonaemia.

Authors:  B Levin; V G Oberholzer; L Sinclair
Journal:  Lancet       Date:  1969-07-26       Impact factor: 79.321

7.  On the availability of intramitochondrial carbamoylphosphate for the extramitochondrial biosynthesis of pyrimidines.

Authors:  P J Natale; G C Tremblay
Journal:  Biochem Biophys Res Commun       Date:  1969-10-22       Impact factor: 3.575

8.  Argininosuccinic acid lyase in human erythrocytes and plasma in health and disease.

Authors:  K Takahara; S Natelson
Journal:  Am J Clin Pathol       Date:  1967-06       Impact factor: 2.493

9.  Ornithine transcarbamylase deficiency in mutant mice I. Studies on the characterization of enzyme defect and suitability as animal model of human disease.

Authors:  I A Qureshi; J Letarte; R Ouellet
Journal:  Pediatr Res       Date:  1979-07       Impact factor: 3.756

10.  Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver.

Authors:  V E Shih; T C Jones; H L Levy; P M Madigan
Journal:  Pediatr Res       Date:  1972-06       Impact factor: 3.756
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