Literature DB >> 7075680

Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin.

P W Kalivas, C B Nemeroff, A J Prange.   

Abstract

Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviors. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 micrograms/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 micrograms/side).

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Year:  1982        PMID： 7075680     DOI： 10.1016/0014-2999(82)90491-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Neurotensin attenuates the reduction in alcohol drinking produced by angiotensin II.

Authors:  L A Grupp; S Harding
Journal:  Psychopharmacology (Berl)       Date:  1996-05       Impact factor: 4.530

2.  Central neurotensin receptor activation produces differential behavioral responses in Fischer and Lewis rats.

Authors:  Pat Bauco; Pierre-Paul Rompré
Journal:  Psychopharmacology (Berl)       Date:  2003-04-08       Impact factor: 4.530

3.  The role of endogenous neurotensin in psychostimulant-induced disruption of prepulse inhibition and locomotion.

Authors:  Ricardo Cáceda; Elisabeth B Binder; Becky Kinkead; Charles B Nemeroff
Journal:  Schizophr Res       Date:  2011-11-21       Impact factor: 4.939

4.  Activation of neurotensin receptor type 1 attenuates locomotor activity.

Authors:  Chelsea A Vadnie; David J Hinton; Sun Choi; YuBin Choi; Christina L Ruby; Alfredo Oliveros; Miguel L Prieto; Jun Hyun Park; Doo-Sup Choi
Journal:  Neuropharmacology       Date:  2014-06-11       Impact factor: 5.250

5.  Association between neurotensin receptor 1 gene polymorphisms and alcohol dependence in a male Han Chinese population.

Authors:  Hui Ma; Yinglin Huang; Bo Zhang; Yuan Wang; Hong Zhao; Hong Du; Zhengtu Cong; Jingying Li; Gang Zhu
Journal:  J Mol Neurosci       Date:  2013-06-08       Impact factor: 3.444

6.  Comparison of the locomotor-activating effects of bicuculline infusions into the preoptic area and ventral pallidum.

Authors:  Daniel S Zahm; Zachary M Schwartz; Heather N Lavezzi; Leora Yetnikoff; Kenneth P Parsley
Journal:  Brain Struct Funct       Date:  2013-02-20       Impact factor: 3.270

7.  Characteristics of the actions of neurotensin on motor reactions in rats in response to positive and negative conditioned signals.

Authors:  N P Shugalev; N G Yamshchikova; A S Ol'shanskii; A V Stavrovskaya
Journal:  Neurosci Behav Physiol       Date:  2004-03

8.  The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.

Authors:  James B Thomas; Hernán Navarro; Keith R Warner; Brian Gilmour
Journal:  Bioorg Med Chem Lett       Date:  2009-01-15       Impact factor: 2.823

9.  Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.

Authors:  James B Thomas; Angela M Giddings; Robert W Wiethe; Srinivas Olepu; Keith R Warner; Philippe Sarret; Louis Gendron; Jean-Michel Longpre; Yanan Zhang; Scott P Runyon; Brian P Gilmour
Journal:  J Med Chem       Date:  2014-06-05       Impact factor: 7.446
  9 in total

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