Improved assessment of plasma lipoprotein patterns. IV. Simple preparation of a lyophilized control serum containing intact human plasma lipoproteins.

Addition of sucrose (413-825 mmol/L) to human serum allows plasma lipoproteins to be lyophilized without denaturation. A control serum so prepared is especially suited for use in monitoring determinations of apolipoproteins and quantitative lipoprotein electrophoresis. It is clear upon reconstitution; hence, the described procedure may also be useful for preparation of control sera for general clinical chemistry without de-lipoproteinization.