Literature DB >> 7074739

The potentiation of warfarin anticoagulation by amiodarone.

A Hamer, T Peter, W J Mandel, M M Scheinman, D Weiss.   

Abstract

The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.

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Year:  1982        PMID： 7074739     DOI： 10.1161/01.cir.65.5.1025

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


  27 in total

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