| Literature DB >> 7074285 |
F Bloom, P Lad, Q Pittman, J Rogers.
Abstract
1 Sprague-Dawley rats (n = 72) weighing from 125 to 450 g were injected intraperitoneally (i.p.) with 16% (w/v) ethanol to provide 1, 2 or 3 g/kg doses. 2 Resulting blood alcohol levels (BALs) demonstrated a general inadequacy of dose/body weight (g/kg) formulations of ethanol to provide uniform BALs in animals of different weights. 3 BAL differences between heavier and lighter rats were not well accounted for by developmental changes in liver weight or alcohol dehydrogenase activity. 4 From the data, a table was derived of more appropriate ethanol injection volumes to produce 0-300 mg% BALs (20 mg% increments) in rats from 100-500 g (10 g increments).Entities:
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Year: 1982 PMID： 7074285 PMCID： PMC2071445 DOI： 10.1111/j.1476-5381.1982.tb08780.x
Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739