Literature DB >> 7073949

Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.

J C Williams, B A Gusterson, R C Coombes.   

Abstract

N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis.

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Year:  1982        PMID： 7073949      PMCID： PMC2010985          DOI： 10.1038/bjc.1982.96

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  24 in total

1.  Metastasis results from preexisting variant cells within a malignant tumor.

Authors:  I J Fidler; M L Kripke
Journal:  Science       Date:  1977-08-26       Impact factor: 47.728

2.  Selection of successive tumour lines for metastasis.

Authors:  I J Fidler
Journal:  Nat New Biol       Date:  1973-04-04

3.  Selection and altered properties of brain-colonising metastatic melanoma.

Authors:  K W Brunson; G Beattie; G L Nicolsin
Journal:  Nature       Date:  1978-04-06       Impact factor: 49.962

4.  Heterogeneity and variability of artificial lung colony-forming ability among clones from mouse fibrosarcoma.

Authors:  N Suzuki; H R Withers; M W Koehler
Journal:  Cancer Res       Date:  1978-10       Impact factor: 12.701

5.  Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin.

Authors:  M L Kripke; E Gruys; I J Fidler
Journal:  Cancer Res       Date:  1978-09       Impact factor: 12.701

6.  Induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low-metastatic H-2 heterozygous tumor cell line into an H-2 incompatible parental strain.

Authors:  R S Kerbel; R R Twiddy; D M Robertson
Journal:  Int J Cancer       Date:  1978-11-15       Impact factor: 7.396

7.  Selection and biologic properties of malignant variants of a murine lymphosarcoma.

Authors:  K W Brunson; G L Nicolson
Journal:  J Natl Cancer Inst       Date:  1978-12       Impact factor: 13.506

8.  Suitability of rat mammary adenocarcinoma 13762 as a model for BCG immunotherapy.

Authors:  J W Kreider; G L Bartlett; D M Purnell
Journal:  J Natl Cancer Inst       Date:  1976-04       Impact factor: 13.506

Review 9.  Specificity of arrest, survival, and growth of selected metastatic variant cell lines.

Authors:  G L Nicolson; K W Brunson; I J Fidler
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

10.  Liver-colonizing melanoma cells selected from B-16 melanoma.

Authors:  T Tao; A Matter; K Vogel; M M Burger
Journal:  Int J Cancer       Date:  1979-06-15       Impact factor: 7.396
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  3 in total

Review 1.  Stem cells and the development of mammary cancers in experimental rats and in humans.

Authors:  P S Rudland
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

2.  Effect of human recombinant tumour necrosis factor and rat gamma interferon on nitrosomethylurea-induced mammary tumours.

Authors:  P Shah; P H van der Meide; T Borman; N Schroeder; J M Bliss; R C Coombes
Journal:  Br J Cancer       Date:  1989-02       Impact factor: 7.640

3.  Do metastases arise from pre-existing subpopulations of cancer cells?

Authors:  L Weiss; J C Holmes; P M Ward
Journal:  Br J Cancer       Date:  1983-01       Impact factor: 7.640
  3 in total

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