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Literature DB >> 7073947

Growth delay in small EMT6 spheroids induced by cytotoxic drugs and its modification by misonidazole pretreatment under hypoxic conditions.

Abstract

Experiments have been carried out to determine whether the growth delay induced in small EMT6 spheroids (approximately 250 micrometers in diameter) by a range of cytotoxic drugs can be increased by pre-incubation of the spheroids under hypoxic conditions with misonidazole (MISO). Hypoxic pre-incubation was for 3 or 5 h in the presence of 5 mM MISO, and caused a growth delay of about 1 day or 2 days respectively. Sensitization to nitrogen mustard (HN2), melphalan, chlorambucil, BCNU and CCNU was seen, but the shapes of the dose-response curves and the ratio of effects for 3 h and 5 h pretreatment varied between the drugs. In contrast to the other agents, hypoxic pre-incubation with MISO reduced the spheroid response to adriamycin.

Entities: Chemical Disease Gene

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Year: 1982 PMID： 7073947 PMCID： PMC2010993 DOI： 10.1038/bjc.1982.93

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

7 in total

1. Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation.

Authors: T W Wong; G F Whitmore; S Gulyas
Journal: Radiat Res Date: 1978-09 Impact factor: 2.841

2. Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.

Authors: J J Clement; M S Gorman; I Wodinsky; R Catane; R K Johnson
Journal: Cancer Res Date: 1980-11 Impact factor: 12.701

3. The response of EMT6 tumor spheroids to combined treatment with misonidazole and either nitrogen mustard, adriamycin, or BCNU.

Authors: P R Twentyman
Journal: Cancer Clin Trials Date: 1980

4. Cell-cycle inhibition by misonidazole of human cells cultivated in vitro under aerobic conditions.

Authors: T Lindmo; E O Pettersen; E Wibe
Journal: Br J Cancer Date: 1979-11 Impact factor: 7.640

5. Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival.

Authors: P R Twentyman
Journal: Br J Cancer Date: 1980-08 Impact factor: 7.640

6. The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.

Authors: I J Stratford; G E Adams; M R Horsman; S Kandaiya; S Rajaratnam; E Smith; C Williamson
Journal: Cancer Clin Trials Date: 1980

7. In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.

Authors: I F Tannock
Journal: Br J Cancer Date: 1980-12 Impact factor: 7.640

7 in total

10 in total

Review 1. Multicellular spheroids. A review on cellular aggregates in cancer research.

Authors: W Mueller-Klieser
Journal: J Cancer Res Clin Oncol Date: 1987 Impact factor: 4.553

2. In vitro potentiation of BCNU activity in rat brain tumour cells pretreated with misonidazole.

Authors: D W Siemann; K Wolf; S Morrissey; K T Wheeler
Journal: Br J Cancer Date: 1984-06 Impact factor: 7.640

3. Biological properties of a tumour cell line (NB1-G) derived from human neuroblastoma.

Authors: R Carachi; T Raza; D Robertson; T W Wheldon; L Wilson; A Livingstone; V van Heyningen; G Spowart; P Middleton; J R Gosden
Journal: Br J Cancer Date: 1987-04 Impact factor: 7.640

4. The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids.

Authors: D J Kerr; T E Wheldon; A M Kerr; R I Freshney; S B Kaye
Journal: Br J Cancer Date: 1986-09 Impact factor: 7.640

Growth delay in small EMT6 spheroids induced by cytotoxic drugs and its modification by misonidazole pretreatment under hypoxic conditions.

1. Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation.

2. Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.

3. The response of EMT6 tumor spheroids to combined treatment with misonidazole and either nitrogen mustard, adriamycin, or BCNU.

4. Cell-cycle inhibition by misonidazole of human cells cultivated in vitro under aerobic conditions.

5. Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival.

6. The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.

7. In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.

Review 1. Multicellular spheroids. A review on cellular aggregates in cancer research.

2. In vitro potentiation of BCNU activity in rat brain tumour cells pretreated with misonidazole.

3. Biological properties of a tumour cell line (NB1-G) derived from human neuroblastoma.

4. The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids.

5. Antitumour activity and pharmacokinetics of niosome encapsulated adriamycin in monolayer, spheroid and xenograft.

6. 131I-meta-iodobenzylguanidine therapy in neuroblastoma spheroids of different sizes.

7. The effects of alpha and gamma interferons on human lung cancer cells grown in vitro or as xenografts in nude mice.

8. Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU.

9. Effect of misonidazole pretreatment on nitrogen mustard-induced DNA cross-linking in mouse tissues in vivo.

10. An investigation of the possibility of chemosensitization by clinically achievable concentrations of misonidazole.