Rebound gentamicin levels after hemodialysis.

After observing the phenomenon clinically, seven post-hemodialysis patients were studied for a rebound effect of gentamicin levels. Serum gentamicin levels were obtained immediately after dialysis and 1 hr postdialysis. An average 25.7% rebound occurred in the serum levels. A slow redistribution of gentamicin out of tissue into the serum is the probable mechanism. This data suggests that a short time period should be allowed before postdialysis levels are obtained to determine gentamicin replacement doses.