Literature DB >> 7071604

Human aldehyde dehydrogenase: mechanism of inhibition of disulfiram.

R C Vallari, R Pietruszko.   

Abstract

Disulfiram labeled with carbon-14 reacts specifically with human liver aldehyde dehydrogenase E1 with loss of catalytic activity and no incorporation of label. Carbon-14-labeled diethyldithiocarbamate is formed and the number of enzyme sulfhydryl groups decreases from 34 to 30 during this process. Activity is recovered by-mercaptoethanol but not by glutathione, the physiological reducing agent.

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Year:  1982        PMID： 7071604     DOI： 10.1126/science.7071604

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  40 in total

1.  Effect of enzyme inhibitors on protein quaternary structure determined by on-line size exclusion chromatography-microelectrospray ionization mass spectrometry.

Authors:  M L Shen; L M Benson; K L Johnson; J J Lipsky; S Naylor
Journal:  J Am Soc Mass Spectrom       Date:  2001-01       Impact factor: 3.109

2.  Modulation of the reactivity of the essential cysteine residue of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa.

Authors:  Lilian González-Segura; Roberto Velasco-García; Rosario A Muñoz-Clares
Journal:  Biochem J       Date:  2002-02-01       Impact factor: 3.857

Review 3.  New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer.

Authors:  Di Chen; Q Ping Dou
Journal:  Expert Opin Ther Targets       Date:  2008-06       Impact factor: 6.902

Review 4.  The role of non-P450 enzymes in drug oxidation.

Authors:  C Beedham
Journal:  Pharm World Sci       Date:  1997-12

5.  Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner.

Authors:  Alex G Dalecki; Mehri Haeili; Santosh Shah; Alexander Speer; Michael Niederweis; Olaf Kutsch; Frank Wolschendorf
Journal:  Antimicrob Agents Chemother       Date:  2015-06-01       Impact factor: 5.191

Review 6.  Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.

Authors:  Emily L Ricq; Jacob M Hooker; Stephen J Haggarty
Journal:  Psychiatry Clin Neurosci       Date:  2016-09-07       Impact factor: 5.188

7.  Disulfiram lowers Ca2+, Mg(2+)-ATPase activity of rat brain synaptosomes.

Authors:  S N Nagendra; K M Rao; M N Subhash; K T Shetty
Journal:  Neurochem Res       Date:  1994-12       Impact factor: 3.996

8.  Inhibition of erythrocyte aldehyde dehydrogenase activity and elimination kinetics of diethyldithiocarbamic acid methyl ester and its monothio analogue after administration of single and repeated doses of disulfiram to man.

Authors:  B Johansson; Z Stankiewicz
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

9.  Segment-specific pattern of sympathetic preganglionic projections in the chicken embryo spinal cord is altered by retinoids.

Authors:  C J Forehand; E B Ezerman; J P Goldblatt; D L Skidmore; J C Glover
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

10.  Inactivation of horse liver mitochondrial aldehyde dehydrogenase by disulfiram. Evidence that disulfiram is not an active-site-directed reagent.

Authors:  C G Sanny; H Weiner
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857
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