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Literature DB >> 7070959

The effect of pulmonary stretch receptor activity on the respiratory response to ammonia-inhalation.

Abstract

The contribution of pulmonary stretch receptor (SR) activity to the changes in breathing pattern (f, VT, tI, tE, tI: tE) following inhalation of ammonia vapour has been studied in rabbits at three levels of lung distension, i.e., three levels of SR activity, and during reversible SO2-blockade of SR. The result show that the increase in breathing frequency (f) and the decrease in tidal volume (VT) due to ammonia inhalation are almost identical for animals with and without blockade of SR, whereas the duration of inspiration and expiration (tI, tE) as well as their relationship (tI:tE) vary considerably, the variations depending on the level of SR activity. For a given tI the expiration was longer in animals with SR intact than in animals with SR blocked. It is concluded that in rabbits the increased activity of SR after inhalation of ammonia counteracts significantly the predominant effects of irritant (deflation) receptor stimulation, thus rendering possible a longer expiration.

Entities: Chemical Disease Species

Mesh：

Substances：
Sulfur Dioxide
Ammonia

Year: 1982 PMID： 7070959 DOI： 10.1007/bf00584311

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

11 in total

1. The activity of pulmonary stretch receptors during bronchoconstriction, pulmonary oedema, atelectasis and breathing against a resistance.

Authors: J G WIDDICOMBE
Journal: J Physiol Date: 1961-12 Impact factor: 5.182

2. Studies on the role of the lung deflation reflex.

Authors: E A Koller; P Ferrer
Journal: Respir Physiol Date: 1970-09

3. Discharge patterns of the lung stretch receptors and activation of deflation fibres in anaphylactic bronchial asthma.

Authors: E A Koller; P Ferrer
Journal: Respir Physiol Date: 1973-01

4. [Respiration and circulation in anaphylactic bronchial asthma in guinea pigs. 3. Pulmonary changes during the asthma attack and the inspiratory reaction].

Authors: E A Koller
Journal: Helv Physiol Pharmacol Acta Date: 1968

5. Approach to a quantitative differentiation between the respiratory effects evoked from the lung stretch and the lung deflation receptors during thoracic compression.

Authors: E A Koller; D G Rüegg; P Ferrer
Journal: Experientia Date: 1971-02-15

The effect of pulmonary stretch receptor activity on the respiratory response to ammonia-inhalation.

1. The activity of pulmonary stretch receptors during bronchoconstriction, pulmonary oedema, atelectasis and breathing against a resistance.

2. Studies on the role of the lung deflation reflex.

3. Discharge patterns of the lung stretch receptors and activation of deflation fibres in anaphylactic bronchial asthma.

4. [Respiration and circulation in anaphylactic bronchial asthma in guinea pigs. 3. Pulmonary changes during the asthma attack and the inspiratory reaction].

5. Approach to a quantitative differentiation between the respiratory effects evoked from the lung stretch and the lung deflation receptors during thoracic compression.

6. Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions.

7. The mechanism of rapid shallow breathing due to histamine and phenyldiguanide in cats and rabbits.

8. Lung reflexes in rabbits during pulmonary stretch receptor block by sulphur dioxide.

9. The Hering-Breuer reflexes in the bronchial asthma attack.

10. Stretch receptor activity during irritant-induced tachypnoea in the rabbit.

1. Vagal control of the breathing pattern and respiratory mechanics in the adult and newborn rabbit.

2. Location-dependent characteristics of pulmonary stretch receptor activity in the rabbit.