Literature DB >> 7070714

Diazepam enhancement of low affinity GABA binding to rat brain membranes.

J H Skerritt, M Willow, G A Johnston.   

Abstract

Diazepam (3 nM-3 microM) enhanced GABA binding to well-washed synaptosomal membranes in a concentration-dependent manner. Half maximal enhancement occurred at 20 nM diazepam. Kinetic analysis by non-linear Scatchard analysis revealed that the primary action of diazepam was to increase the affinity of GABA binding to a low affinity site. These results support electrophysiological and other biochemical observations of benzodiazepine-GABA interactions.

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Year:  1982        PMID： 7070714     DOI： 10.1016/0304-3940(82)90365-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  22 in total

Review 1.  Biochemical dissection of the gamma-aminobutyrate synapse.

Authors:  A J Turner; S R Whittle
Journal:  Biochem J       Date:  1983-01-01       Impact factor: 3.857

Review 2.  Pharmacology of benzodiazepine receptors: an update.

Authors:  W Sieghart
Journal:  J Psychiatry Neurosci       Date:  1994-01       Impact factor: 6.186

3.  Interactions of some anaesthetic, convulsant, and anticonvulsant drugs at GABA-benzodiazepine receptor-ionophore complexes in rat brain synaptosomal membranes.

Authors:  J H Skerritt; G A Johnston
Journal:  Neurochem Res       Date:  1983-10       Impact factor: 3.996

4.  Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes.

Authors:  J H Skerritt; G A Johnston; T Katsikas; J Tabar; G M Nicholson; P R Andrews
Journal:  Neurochem Res       Date:  1983-10       Impact factor: 3.996

5.  Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.

Authors:  P Ferrero; A Guidotti; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

Review 6.  Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Authors:  Biljana Antonijevic; Milos P Stojiljkovic
Journal:  Clin Med Res       Date:  2007-03

7.  Diazepam antagonizes GABA- and muscimol-induced changes of acetylcholine release in slices of guinea-pig cerebral cortex.

Authors:  S Tanganelli; C Bianchi; L Beani
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-09       Impact factor: 3.000

8.  Changes in benzodiazepine-GABA receptor coupling in an accumbens-habenula circuit after chronic diazepam treatment.

Authors:  R R Brett; J A Pratt
Journal:  Br J Pharmacol       Date:  1995-11       Impact factor: 8.739

9.  Effects of chronic melatonin administration on GABA and diazepam binding in rat brain.

Authors:  L P Niles; D S Pickering; M A Arciszewski
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

10.  Development of tolerance to anxiolytic effects of chlordiazepoxide in elevated plus-maze test and decrease of GABAA receptors.

Authors:  S Ishihara; M Hiramatsu; T Kameyama; T Nabeshima
Journal:  J Neural Transm Gen Sect       Date:  1993
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