Literature DB >> 7068913

Serum glutamate dehydrogenase is not a reliable marker of liver cell necrosis in alcoholics.

W J Jenkins, S B Rosalki, Y Foo, P J Scheuer, E Nemesanszky, S Sherlock.   

Abstract

Serum glutamate dehydrogenase (EC 1.4.1.3.) activity was measured in 73 hospital patients who had a history of chronic alcohol abuse and who all had a liver biopsy performed. High levels of serum GDH activity occurred in those patients with recent excess alcohol consumption independently of the underlying liver histology, and did not discriminate between those patients with and those without alcoholic hepatitis.

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Year:  1982        PMID： 7068913      PMCID： PMC497499          DOI： 10.1136/jcp.35.2.207

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  8 in total

1.  [Methods and value of determination of glutamic acid dehydrogenase activity in the serum. A contribution to the importance of examination of enzyme relations in the serum].

Authors:  E SCHMIDT; F W SCHMIDT
Journal:  Klin Wochenschr       Date:  1962-09-15

2.  A note on the spectrometric assay of glutamic-oxalacetic transaminase in human blood serum.

Authors:  A KARMEN
Journal:  J Clin Invest       Date:  1955-01       Impact factor: 14.808

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Elevated serum gamma-glutamyl-transferase (transpeptidase) and histological liver damage in alcoholism.

Authors:  A Wu; G Slavin; A J Levi
Journal:  Am J Gastroenterol       Date:  1976-04       Impact factor: 10.864

5.  Serum -glutamyl transpeptidase activity in alcoholism.

Authors:  S B Rosalki; D Rau
Journal:  Clin Chim Acta       Date:  1972-06       Impact factor: 3.786

6.  Chronic alcoholism with fatty metamorphosis of the liver. Mitochondrial alterations in hepatic cells.

Authors:  D J Svoboda; R T Manning
Journal:  Am J Pathol       Date:  1964-04       Impact factor: 4.307

7.  Mitochondrial enzyme activities in liver biopsies from patients with alcoholic liver disease.

Authors:  W J Jenkins; T J Peters
Journal:  Gut       Date:  1978-05       Impact factor: 23.059

8.  Glutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic.

Authors:  L Van Waes; C S Lieber
Journal:  Br Med J       Date:  1977-12-10
  8 in total
  2 in total

Review 1.  Clinical use of serum enzymes in liver disease.

Authors:  J J Reichling; M M Kaplan
Journal:  Dig Dis Sci       Date:  1988-12       Impact factor: 3.199

Review 2.  Clinical pathology of alcohol.

Authors:  V Marks
Journal:  J Clin Pathol       Date:  1983-04       Impact factor: 3.411
  2 in total

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