Literature DB >> 7068281

The effect of age on the pharmacokinetics of oxprenolol.

M J Kendall, C P Quarterman.   

Abstract

The pharmacokinetics of oxprenolol have been studied in young and healthy elderly volunteers. Drug concentrations in plasma and urine have been measured after a single 80-mg dose of oxprenolol and again after repeated administration (80 mg twice daily) for a period of 1 week. It has been shown that multiple dosing does not result in oxprenolol accumulation in either group and that age has no effect on the pharmacokinetics of this drug.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7068281

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Ther Toxicol        ISSN： 0174-4879


  6 in total

Review 1.  Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations.

Authors:  Arduino A Mangoni
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

Review 2.  Antihypertensive therapy in the aged patient. Clinical pharmacokinetic considerations.

Authors:  R W Piepho; K J Fendler
Journal:  Drugs Aging       Date:  1991-05       Impact factor: 3.923

3.  Pharmacokinetics of metoprolol in healthy, elderly, non-smoking individuals after a single dose and two weeks of treatment.

Authors:  M Larsson; S Landahl; P Lundborg; C G Regårdh
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

4.  A comparison of the pharmacokinetics of atenolol, metoprolol, oxprenolol and propranolol in elderly hypertensive and young healthy subjects.

Authors:  J W Rigby; A K Scott; G M Hawksworth; J C Petrie
Journal:  Br J Clin Pharmacol       Date:  1985-10       Impact factor: 4.335

5.  Comparison of pharmacokinetic profiles of single and multiple doses of a slow release Oros oxprenolol delivery system in young normotensive and elderly hypertensive subjects.

Authors:  I D Bradbrook; M Babiker; P Crome; H C Gillies; P J Morrison; H J Rogers; P Shotton
Journal:  Br J Clin Pharmacol       Date:  1986-04       Impact factor: 4.335

Review 6.  Clinical pharmacokinetic considerations in the elderly. An update.

Authors:  S Dawling; P Crome
Journal:  Clin Pharmacokinet       Date:  1989-10       Impact factor: 6.447
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.