Literature DB >> 7068215

Biological activities of toxins A and B of Clostridium difficile.

D M Lyerly, D E Lockwood, S H Richardson, T D Wilkins.   

Abstract

Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 7068215      PMCID： PMC351167          DOI： 10.1128/iai.35.3.1147-1150.1982

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  22 in total

1.  Intestinal fluid accumulation induced by oral challenge with Vibrio cholerae or cholera toxin in infant mice.

Authors:  V Baselski; R Briggs; C Parker
Journal:  Infect Immun       Date:  1977-03       Impact factor: 3.441

2.  Gastrointestinal and systemic toxicity of fecal extracts from hamsters with clindamycin-induced colitis.

Authors:  G D Rifkin; J Silva; R Fekety
Journal:  Gastroenterology       Date:  1978-01       Impact factor: 22.682

3.  Antibiotic-induced lethal enterocolitis in hamsters: studies with eleven agents and evidence to support the pathogenic role of toxin-producing Clostridia.

Authors:  J G Bartlett; T W Chang; N Moon; A B Onderdonk
Journal:  Am J Vet Res       Date:  1978-09       Impact factor: 1.156

4.  Experimental clindamycin-associated colitis in rabbits. Evidence of toxin-mediated mucosal damage.

Authors:  L Katz; J T LaMont; J S Trier; E B Sonnenblick; S W Rothman; S A Broitman; S Rieth
Journal:  Gastroenterology       Date:  1978-02       Impact factor: 22.682

5.  Identification of Clostridium difficile as a cause of pseudomembranous colitis.

Authors:  R H George; J M Symonds; F Dimock; J D Brown; Y Arabi; N Shinagawa; M R Keighley; J Alexander-Williams; D W Burdon
Journal:  Br Med J       Date:  1978-03-18

6.  Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.

Authors:  J G Bartlett; A B Onderdonk; R L Cisneros; D L Kasper
Journal:  J Infect Dis       Date:  1977-11       Impact factor: 5.226

7.  Production of vascular permeability factor by enterotoxigenic Escherichia coli isolated from man.

Authors:  D J Evans; D G Evans; S L Gorbach
Journal:  Infect Immun       Date:  1973-11       Impact factor: 3.441

8.  Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.

Authors:  J G Bartlett; T W Chang; M Gurwith; S L Gorbach; A B Onderdonk
Journal:  N Engl J Med       Date:  1978-03-09       Impact factor: 91.245

9.  Clindamycin-induced enterocolitis in hamsters.

Authors:  R H Lusk; R Fekety; J Silva; R A Browne; D H Ringler; G D Abrams
Journal:  J Infect Dis       Date:  1978-04       Impact factor: 5.226

10.  Clostridium difficile and the aetiology of pseudomembranous colitis.

Authors:  H E Larson; A B Price; P Honour; S P Borriello
Journal:  Lancet       Date:  1978-05-20       Impact factor: 79.321
View more
  100 in total

1.  The involvement of macrophage-derived tumour necrosis factor and lipoxygenase products on the neutrophil recruitment induced by Clostridium difficile toxin B.

Authors:  M H Souza; A A Melo-Filho; M F Rocha; D M Lyerly; F Q Cunha; A A Lima; R A Ribeiro
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

2.  Localization of two epitopes recognized by monoclonal antibody PCG-4 on Clostridium difficile toxin A.

Authors:  S M Frey; T D Wilkins
Journal:  Infect Immun       Date:  1992-06       Impact factor: 3.441

3.  Evaluation of an enzyme immunoassay for detection of Clostridium difficile toxin A.

Authors:  K Tsimidis; A E Simor
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-06       Impact factor: 3.267

4.  Passive immunization of hamsters against disease caused by Clostridium difficile by use of bovine immunoglobulin G concentrate.

Authors:  D M Lyerly; E F Bostwick; S B Binion; T D Wilkins
Journal:  Infect Immun       Date:  1991-06       Impact factor: 3.441

5.  Enterotoxigenicity of mature 45-kilodalton and processed 35-kilodalton forms of hemagglutinin protease purified from a cholera toxin gene-negative Vibrio cholerae non-O1, non-O139 strain.

Authors:  A Ghosh; D R Saha; K M Hoque; M Asakuna; S Yamasaki; H Koley; S S Das; M K Chakrabarti; A Pal
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

6.  Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis.

Authors:  I C Cavalcante; M V Castro; A R F Barreto; G W Sullivan; M Vale; P R C Almeida; J Linden; J M Rieger; F Q Cunha; R L Guerrant; R A Ribeiro; G A C Brito
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

7.  Ileal smooth muscle motility depression on rabbit induced by toxin A from Clostridium difficile.

Authors:  Crystianne Calado Lima; João Luis Carvalho-de-Souza; Aldo Angelo Moreira Lima; José Henrique Leal-Cardoso
Journal:  Dig Dis Sci       Date:  2008-06       Impact factor: 3.199

8.  Purification and characterization of an enterotoxin from Bacteroides fragilis.

Authors:  R L Van Tassell; D M Lyerly; T D Wilkins
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

9.  Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.

Authors:  G Corthier; F Dubos; P Raibaud
Journal:  Appl Environ Microbiol       Date:  1985-01       Impact factor: 4.792

10.  Two bacteriophages of Clostridium difficile.

Authors:  D E Mahony; P D Bell; K B Easterbrook
Journal:  J Clin Microbiol       Date:  1985-02       Impact factor: 5.948
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.