Literature DB >> 7068178

Role of angiotensinogen in blood pressure homeostasis.

J Gardes, J Bouhnik, E Clauser, P Corvol, J Menard.   

Abstract

The role of angiotensinogen in blood pressure control was assessed in normotensive rats by observing the changes resulting from inhibition by specific rat angiotensinogen antiserum. The antiserum decreased blood pressure in rats on normal sodium as well as sodium-free diets (respectively delta BP = -30 +/- 6 mm Hg and -42 +/- 8 mm Hg). In binephrectomized sodium-replete rats, administration of antiserum did not reduce blood pressure, whereas in sodium-depleted animals it slightly decreased blood pressure by 11 +/- 3 mm Hg. These results suggest that angiotensinogen participates in the regulation of blood pressure in normotensive rats, even in the sodium-replete state.

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Year:  1982        PMID： 7068178     DOI： 10.1161/01.hyp.4.2.185

Source DB:  PubMed          Journal:  Hypertension        ISSN： 0194-911X            Impact factor:   10.190


  21 in total

1.  A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al.

Authors:  Curt D Sigmund
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-10-29       Impact factor: 3.619

Review 2.  Success and failure of vaccines against renin-angiotensin system components.

Authors:  Morris J Brown
Journal:  Nat Rev Cardiol       Date:  2009-08-25       Impact factor: 32.419

Review 3.  Circulating and tissue angiotensin systems.

Authors:  D J Campbell
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

4.  Haplotypes of angiotensinogen in essential hypertension.

Authors:  X Jeunemaitre; I Inoue; C Williams; A Charru; J Tichet; M Powers; A M Sharma; A P Gimenez-Roqueplo; A Hata; P Corvol; J M Lalouel
Journal:  Am J Hum Genet       Date:  1997-06       Impact factor: 11.025

5.  Variants and haplotypes in angiotensinogen gene are associated with plasmatic angiotensinogen level in Mexican population.

Authors:  Eros Balam-Ortiz; Adolfo Esquivel-Villarreal; Luis Alfaro-Ruiz; Karol Carrillo; Adela Elizalde; Trinidad Gil; Maki Urushihara; Hiroyuki Kobori; Gerardo Jimenez-Sanchez
Journal:  Am J Med Sci       Date:  2011-09       Impact factor: 2.378

Review 6.  Angiotensinogen variants and human hypertension.

Authors:  X Jeunemaitre; A P Gimenez-Roqueplo; J Célérier; P Corvol
Journal:  Curr Hypertens Rep       Date:  1999 Feb-Mar       Impact factor: 5.369

7.  Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.

Authors:  Sungmi Park; Xuebo Liu; Deborah R Davis; Curt D Sigmund
Journal:  Hypertension       Date:  2012-04-30       Impact factor: 10.190

8.  Local generation of angiotensin II as a mechanism of regulation of peripheral vascular tone in the rat.

Authors:  J A Oliver; R R Sciacca
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

9.  Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota.

Authors:  M Fornage; S T Turner; C F Sing; E Boerwinkle
Journal:  Hum Genet       Date:  1995-09       Impact factor: 4.132

10.  Genetic control of blood pressure and the angiotensinogen locus.

Authors:  H S Kim; J H Krege; K D Kluckman; J R Hagaman; J B Hodgin; C F Best; J C Jennette; T M Coffman; N Maeda; O Smithies
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205
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