Literature DB >> 7067724

[Pharmacokinetic study of 3H-stiripentol in rats (author's transl)].

F Pieri, R Wegmann, J Astoin.   

Abstract

The radioactive constituents of blood, urine, and bile specimens from Wistar Rats, following intravenous administration of 3H-stiripentol were analyzed, in parallel with samples of: liver, lung, kidneys, testis, heart, brain, cerebellum, and medulla. These investigations yielded the following results: 3H-Stiripentol was quantitatively and rapidly absorbed and metabolized by Wistar rats, due to intense metabolism in the liver. The cerebellum and medulla accumulated radioactivity, which was probably related to the pharmacological effects of this drug.

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Year:  1982        PMID： 7067724     DOI： 10.1007/BF03189536

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  2 in total

1.  Estimation of the pharmacokinetic parameters of the two-compartment open model from post-infusion plasma concentration data.

Authors:  M Gibaldi
Journal:  J Pharm Sci       Date:  1969-09       Impact factor: 3.534

2.  [Pharmaco-cellular enzymology of the mode of action of Stiripentol during cardiazolic epilepsia--IV. Cellular and tissular repartition of 3H-Stiripentol (author's transl)].

Authors:  R Wegmann; A Ilies; M Aurousseau; F Patte
Journal:  Cell Mol Biol Incl Cyto Enzymol       Date:  1979
  2 in total
  1 in total

Review 1.  New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.

Authors:  M Bebin; T P Bleck
Journal:  Drugs       Date:  1994-08       Impact factor: 9.546
  1 in total

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