Literature DB >> 7067719

Plasma concentrations and pharmacokinetics of misonidazole after intraperitoneal administration to the mouse.

M F Malmary-Nebot, C Labat, M Terrissol, B Martin, J Oustrin.   

Abstract

The pharmacokinetics of misonidazole, a hypoxic-cell radiosensitizer, were determinated after intraperitoneal administration to standardized Balb/c mice. The experimental data was fitted, using non linear analysis, to plasma-concentration curves described by tri-exponential equations derived from a two-compartment model. The pharmacokinetic constants (absorption and elimination coefficients) were determinated.

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Year:  1982        PMID： 7067719     DOI： 10.1007/BF03189538

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  8 in total

1.  Radiosensitizers of hypoxic cells in solid tumors.

Authors:  J F Fowler; G E Adams; J Denekamp
Journal:  Cancer Treat Rev       Date:  1976-12       Impact factor: 12.111

2.  Peripheral neuropathy related to misonidazole: incidence and pathology.

Authors:  R C Urtasun; J D Chapman; M L Feldstein; R P Band; H R Rabin; A F Wilson; B Marynowski; E Starreveld; T Shnitka
Journal:  Br J Cancer Suppl       Date:  1978-06

3.  Nitroheterocyclic drugs as selective radiosensitizers of hypoxic mammalian cells.

Authors:  J D Chapman; A P Reuvers; J Borsa; J S Henderson; R D Migliore
Journal:  Cancer Chemother Rep       Date:  1974 Jul-Aug

4.  Pharmacokinetics and bioavailability of cimetidine in humans.

Authors:  P V Pedersen; R Miller
Journal:  J Pharm Sci       Date:  1980-04       Impact factor: 3.534

5.  The effect of misonidazole on some physiologic parameters in mice.

Authors:  P J Conroy; R von Burg; W Passalacqua; R M Sutherland
Journal:  J Pharmacol Exp Ther       Date:  1980-01       Impact factor: 4.030

6.  Pharmacokinetic and metabolic studies of the hypoxic cell radiosensitizer misonidazole.

Authors:  I R Flockhart; P Large; D Troup; S L Malcolm; T R Marten
Journal:  Xenobiotica       Date:  1978-02       Impact factor: 1.908

7.  Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.

Authors:  S Dische; M I Saunders; M E Lee; G E Adams; I R Flockhart
Journal:  Br J Cancer       Date:  1977-05       Impact factor: 7.640

8.  Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.

Authors:  J M Brown; N Y Yu; P Workman
Journal:  Br J Cancer       Date:  1979-03       Impact factor: 7.640
  8 in total

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